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Yugi2014 - Insulin induced signalling (PFKL phosphorylation) - model 1 Insulin induces phosphorylation and activation of liver-type phosphofructokinase 1, which thereby controls a key reaction in glycolysis. This mechanism is revealed using the mathematical model. In this model, the PFKL ph...
2024-09-02 | BIOMD0000000540 | BioModels
Yugi2014 - Insulin induced signalling (PFKL phosphorylation) - model 2 Insulin induces phosphorylation and activation of liver-type phosphofructokinase 1, which thereby controls a key reaction in glycolysis. This mechanism is revealed using the mathematical model. In this model, the PFKL ph...
2024-09-02 | BIOMD0000000541 | BioModels
To discover novel biomarkers for aortic aneurysm, serum samples of patients with thoracic aortic aneurysm were fractionated, tryptic digested, and subjected to proteome analysis.
ORGANISM(S): Homo Sapiens (human) 
FAO cells, rat hepatoma cells, were stimulated with 1 nM insulin and collected at seven time points for ~60 minutes. Ion metal affinity chromatography (IMAC) was performed to enrich the phosphopeptides. As we used two sets of 4-plex iTRAQ to quantify the peptides from seven samples, we set the inter...
ORGANISM(S): Rattus Rattus (black Rat) 
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. We isolate...
ORGANISM(S): Mus Musculus (mouse) 
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. Htra1-KO m...
ORGANISM(S): Mus Musculus (mouse) 
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