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ProteomicsThe genetic and biochemical basis of human leading strand synthesis
The maintenance of genome stability requires efficient leading strand synthesis by DNA Polymerase Epsilon (Pol). By performing CRISPR genetic screens in cells lacking the POLE4 subunit of Pol we define a genetic map of the factors required to support Pol function in the absence of its accessory subu...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD070472 | Pride
The genetic and biochemical basis of human leading strand synthesis 
ProteomicsBacterial effectors mediate kinase reprogramming through a series of evolutionary conserved amino acids that mimic eukaryotic motifs
Bacteria have evolved numerous biochemical processes that underpin their biology and pathogenesis. The small, non-enzymatic bacterial (Salmonella) effector SteE mediates kinase reprogramming, whereby the canonical serine/threonine host kinase GSK3 gains tyrosine-directed activity towards neosubstrat...
ORGANISM(S): Salmonella sp. WT 
2025-04-25 | PXD058368 | Pride
Mass spectrometry Hdx Kinase 
ProteomicsSalmonella effector kinase SteC is activated by host-mediated phosphorylation
The pathogen Salmonella, which causes significant human morbidity and mortality, encodes an effector kinase, SteC, which mediates actin polymerisation and cell migration of the infected cell. Analysis of the sequence and predicted structure alongside canonical eukaryotic serine-threonine kinases rai...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. T000240 
2026-06-12 | PXD061217 | Pride
Bacterial kinase Hdx Stec Effector Phosphorylation Salmonella Host-pathogen interactions Kinase regulation Non-rd kinase 
ProteomicsHECTD3 is a small HECT E3 ligase with unique features
HECT E3 ligases regulate many cellular processes, yet how they recognise their substrates and synthesise specific types of poly-ubiquitin chains is still incompletely understood. HECTD3, a member of the “other HECT” family, is implicated in the regulation of inflammation, apoptosis, and infection an...
ORGANISM(S): Homo sapiens (Human) 
2026-01-15 | PXD066996 | Pride
E3 ligase Cross-linking 
ProteomicsMpe1 senses the polyadenylation signal in pre-mRNA to promote efficient cleavage and control polyadenylation
Crosslinking mass spectrometry dataset of the Mpe1 and Cft2 bound to the yeast CPF polymerase module. Sulfo-SDA is the crosslinker used.
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2023-01-12 | PXD027482 | JPOST Repository
UnknownBacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs
Not available
S-SCDT-10_1038-S44319-025-00472-Y | biostudies-other
ProteomicsRab5a-VPS34 unnatural amino acid mediated crosslinking
The small GTPase Rab5 has an essential role in sorting vesicles arriving to and leaving the early endosome. One key function of Rab5 in this process is the activation of the primordial phosphatidylinositol 3-kinase VPS34, a lipid kinase that phosphorylates phosphatidylinositol (PI) to generate PI3P....
ORGANISM(S): Homo Sapiens (human) 
2021-12-21 | PXD023533 | JPOST Repository
UnknownSARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination.
Not available
S-EPMC9762734 | biostudies-literature
UnknownImplementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study.
Not available
S-EPMC8940185 | biostudies-literature
UnknownCharacterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study.
Not available
S-EPMC8285118 | biostudies-literature
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