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UnknownIn vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.
Not available
S-EPMC3585072 | biostudies-literature
TranscriptomicsGene Expression in Frontal Cortex in Major Depression and HIV
Major depressive disorder (MDD) is a clinically defined entity with little understanding as to the underlying pathological substrate. Biologically, MDD is characterized by disruption of neurotransmitters, especially serotonin and noradrenaline, which are the main targets of antidepressants. We pre...
ORGANISM(S): Homo sapiens 
2010-02-01 | E-GEOD-17440 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human brain samples from HIV infected individuals with HIV encephalitis vs controls
The neurodegenerative process in HIV encephalitis (HIVE) is associated with extensive damage to the dendritic and synaptic structure that often leads to cognitive impairment. Several mechanisms might be at play, including release of neurotoxins, oxidative stress and decreased activity of neurotrophi...
ORGANISM(S): Homo sapiens 
2007-12-14 | E-GEOD-3489 | biostudies-arrayexpress
ProteomicsAlzheimer's disease proteomics
This project aims to determine how the brain proteome is remodeled in Alzheimer's disease (AD). AD is pathologically characterized by an accumulation of insoluble aggregates composed of Abeta peptides in the brain and is clinically characterized by progressive memory impairment. While the precise pa...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-12-19 | MSV000080431 | MassIVE
Unknownα-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.
Not available
S-EPMC3346117 | biostudies-literature
UnknownExposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.
Not available
S-EPMC4973277 | biostudies-literature
Unknownc-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.
Not available
S-EPMC4014189 | biostudies-literature
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