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MetabolomicsMaslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming
Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and indu...
2017-02-09 | MTBLS240 | MetaboLights
TranscriptomicsRNA Affymetrix microarray analysis of colonic mucosal layer of Apc Min/+ mice fed or not with maslinic acid.
This experiment reports the RNA microarray data from the microarray analysis performed to the RNA isolated from colonic mucosal layer of Apc Min/+ mice. Apc Min/+ mice develop polyps in both the small and large intestine, with a greater incidence of intestinal adenomas observed in the former. We wan...
ORGANISM(S): Mus musculus 
2015-10-31 | E-MTAB-4007 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver to identify hepatic genes differentially expressed in the presence of the maslinic acid in olive oil
Two olive oils only differing in the presence of maslinic acid were prepared. Using DNA microarrays, hepatic gene expression was analysed in apoE-deficient mice with a C57BL/6J genetic background Experiment Overall Design: The experimental animals were 12, two-month old, female, homozygous apoE KO ...
ORGANISM(S): Mus musculus 
2009-01-25 | E-GEOD-7091 | biostudies-arrayexpress
Proteomicsproteome analysis of the antitumor activity of maslinic acid against pancreatic cancer cells
Maslinic acid (MA) is a triterpenoid compound of natural abundance in olive plants possessing numerous biological activities. The effect and molecular mechanism of MA on pancreatic cancer cells remain elusive. Here, we explored the anti-tumor activity of MA on human pancreatic cancer cells and the p...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028303 | Pride
Lc-ms/ms Maslinic acid Pancreatic cancer cells Human 
GenomicsExpression data from Tieghemelin and Maslinic acid-treated C3H mice
Expression data from Tieghemelin and Maslinic acid-treated C3H mice
PRJNA1102386 | ENA
TranscriptomicsExpression data from Tieghemelin and Maslinic acid-treated C3H mice
Gene expression profiling reveals a potential role of Tieghemelin and Maslinic acid in stimulating hair growth in C3H mice. C3H male mice are a model for hair growth, treated with 1% Tieghemelin, 1% Maslinic acid and 1% Minoxidil for 20 days. Microarray gene expression profiling was conducted for tw...
ORGANISM(S): Mus musculus 
2024-04-24 | GSE264424 | GEO
GenomicsExpression data from gastrocnemius muscle of denervated mice ingesting maslinic acid
Expression data from gastrocnemius muscle of denervated mice ingesting maslinic acid
PRJNA750443 | ENA
TranscriptomicsExpression data from gastrocnemius muscle of denervated mice ingesting maslinic acid
Gene expression profiling of the effect of maslinic acid in denervated mice ICR mice were fed either the diet containing 0.27% maslinic acid and the control diet. After 7 days, the sciatic nerve of both legs was cut and a 5-mm piece was excised under anesthesia. Microarray gene expression profiling ...
ORGANISM(S): Mus musculus 
2021-07-29 | GSE181031 | GEO
GenomicsTranscriptome and proteome analysis of the antitumor activity of maslinic acid against pancreatic cancer cells
Transcriptome and proteome analysis of the antitumor activity of maslinic acid against pancreatic cancer cells
PRJNA761113 | ENA
TranscriptomicsA time-course profiling of the effects of maslinic acid on mRNA expression of chemically induced Raji cells.
Maslinic acid is a novel phytochemical reported to exert prominent anti-cancer effects and it was hypothesized that this compound induces cellular apoptosis through the activation of the mitochondrial apoptotic pathway (Martin et al, 2007) — thereby resulting in significant inhibition of cell prolif...
ORGANISM(S): Homo sapiens 
2018-05-02 | GSE39149 | GEO
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