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UnknownP-286Metronomic 5-fluorouracil (5-FU) plus nab-paclitaxel (nab-P), bevacizumab, leucovorin, and oxaliplatin (FABLOx) in patients with metastatic pancreatic cancer (MPC): an open-label, multicenter, single-arm, phase 1/2 study
Not available
S-EPMC4984073 | biostudies-literature
UnknownLonger Leukocyte Telomere Length Predicts Stronger Response to a Workplace Sugar-Sweetened Beverage Sales Ban: An Exploratory Study.
Not available
S-EPMC8257411 | biostudies-literature
UnknownMoving Beyond the Momentum: Innovative Approaches to Clinical Trial Implementation.
Not available
S-EPMC8791825 | biostudies-literature
UnknownAssociation of a Workplace Sales Ban on Sugar-Sweetened Beverages With Employee Consumption of Sugar-Sweetened Beverages and Health.
Not available
S-EPMC6820289 | biostudies-literature
TranscriptomicsRunx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic stem and progenitor cells
The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia. RUNX1 mutations can be early events, creating pre-leukemic stem cells that expand in the bone marrow. Here we show that, counter-intuitively, Runx1 deficient hematopoietic stem and progenitor cells (HSPCs)...
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-67609 | biostudies-arrayexpress
ProteomicsUse of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signaling networks using SILAC-based phosphoproteomics_C4PR
Polo-like kinase 4 (PLK4) is the master regulator of centriole duplication in metazoan organisms. Catalytic activity and protein turnover of PLK4 are tightly coupled in human cells, since changes in PLK4 concentration and catalysis have profound effects on centriole duplication and supernumerary cen...
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD018704 | Pride
Mass spectrometry Centrinone  phosphoproteomics Inhibitor Phosphorylation  substrate Plk4 
TranscriptomicsDysregulation of the Transforming Growth Factor Beta Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia [HuEx-1_0]
Diamond Blackfan Anemia (DBA) is an inherited bone marrow failure syndrome with clinical features of red cell aplasia and variable developmental abnormalities. Most affected patients have heterozygous loss of function mutations in ribosomal protein genes but the pathogenic mechanism is still unknown...
ORGANISM(S): Homo sapiens 
2015-08-31 | E-GEOD-70347 | biostudies-arrayexpress
TranscriptomicsDysregulation of the Transforming Growth Factor Beta Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia [HTA-2_0]
Diamond Blackfan Anemia (DBA) is an inherited bone marrow failure syndrome with clinical features of red cell aplasia and variable developmental abnormalities. Most affected patients have heterozygous loss of function mutations in ribosomal protein genes but the pathogenic mechanism is still unknown...
ORGANISM(S): Homo sapiens 
2015-08-31 | E-GEOD-70348 | biostudies-arrayexpress
UnknownCharacterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine.
Not available
S-EPMC7542678 | biostudies-literature
TranscriptomicsHMGA2 overexpression
Overexpression of high mobility group AT-hook 2 (HMGA2) associated with truncations of its 3’ untranslated region (UTR) with let-7 micro RNA-complementary sequences have been identified in patients with paroxysmal nocturnal hemoglobinuria (PNH). Here, we generated transgenic mice (∆Hmga2 mice) with ...
ORGANISM(S): Mus musculus 
2011-02-06 | E-GEOD-24071 | biostudies-arrayexpress
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