Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts expressing wild type and heterozygous Plk4
A microarray comparison was performed to identify genes over expressed in both wild type and heterozygous Plk4 MEFs
ORGANISM(S): Mus musculus 
2009-09-03 | E-MEXP-2161 | biostudies-arrayexpress
ProteomicsUse of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signaling networks using SILAC-based phosphoproteomics_C4PR
Polo-like kinase 4 (PLK4) is the master regulator of centriole duplication in metazoan organisms. Catalytic activity and protein turnover of PLK4 are tightly coupled in human cells, since changes in PLK4 concentration and catalysis have profound effects on centriole duplication and supernumerary cen...
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD018704 | Pride
Mass spectrometry Centrinone  phosphoproteomics Inhibitor Phosphorylation  substrate Plk4 
GenomicsCentrosome amplification triggers tumorigenesis in p53 deficient epidermis
While aneuploidy is found in more than 90% of solid tumors, it is unclear whether aneuploidy is the cause or the consequence of tumorigenesis. Different mouse models deficient in centrosomal or spindle checkpoint proteins that induce aneuploidy show either a promotion or a decrease in tumorigenesis ...
ORGANISM(S): Mus musculus 
2015-10-27 | E-MTAB-3733 | biostudies-arrayexpress
TranscriptomicsGene expression comparison of MCF10A cells with and without extra centrosomes through overexpression of PLK4
The presence of extra centrosomes is a feature of human tumours. However, it is unclear what are the changes elicited by the presence of these abnormalities. To determine the changes in gene expression induced by centrosome amplification, human mammary epithelial cells, MCF10A, expressing a doxycycl...
ORGANISM(S): Homo sapiens 
2018-02-10 | E-MTAB-6415 | biostudies-arrayexpress
ProteomicsMcIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation
The centriole duplication cycle must be tightly controlled and coordinated with the chromosome cycle to maintain a proper number of centrioles in cells. Aberrations in centriole biogenesis can lead to cancer, developmental disorders and ciliopathies, yet the molecular determinants of centriole numbe...
ORGANISM(S): Homo sapiens (Human) 
2025-12-02 | PXD037043 | Pride
Mcidas Proteomics Phosphorylation Cell cycle Centrosome Plk4 
ProteomicsHuman PLK4 phosphorylation sides mapping
Mapping the phosphorylation sides on the human Polo-like kinase 4 (PLK4).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-08-30 | MSV000084261 | MassIVE
ProteomicsIdentification of Plk4 cryptic polo-box-binding proteins
Identification of Plk4-binding proteins and investigation of the underlying mechanism of how Plk4 regulates centriole duplication.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-07 | MSV000094032 | MassIVE
GenomicsThe ubiquitin ligase TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
The ubiquitin ligase TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
PRJNA623614 | ENA
TranscriptomicsThe ubiquitin ligase TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
We show synthetic lethality between PLK4 inhibition-mediated centrosome loss and the overexpression of the ubiquitin ligase TRIM37 in cancer cells with amplification of Chr17q
ORGANISM(S): Homo sapiens 
2020-09-18 | GSE148263 | GEO
GenomicsSingle-cell whole genome sequencing of murine T-cell lymphoma with Mad2 knockout or transient Plk4 overexpression
Single-cell whole genome sequencing of murine T-cell lymphoma with Mad2 knockout or transient Plk4 overexpression
PRJEB41176 | ENA
Sort   by:  
 Page size