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ProteomicsMcIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation
The centriole duplication cycle must be tightly controlled and coordinated with the chromosome cycle to maintain a proper number of centrioles in cells. Aberrations in centriole biogenesis can lead to cancer, developmental disorders and ciliopathies, yet the molecular determinants of centriole numbe...
ORGANISM(S): Homo sapiens (Human) 
2025-12-02 | PXD037043 | Pride
Mcidas Proteomics Phosphorylation Cell cycle Centrosome Plk4 
GenomicsGenes regulated by MCIDAS
Cytoplasmic MCIDAS organizes de novo centriole biogenesis in multiciliated cells
PRJEB77353 | ENA
UnknownDisruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development.
Not available
S-EPMC9345885 | biostudies-literature
UnknownGEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program.
Not available
S-EPMC10023806 | biostudies-literature
GenomicsGEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program
GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program
PRJNA675857 | ENA
UnknownDefects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice.
Not available
S-EPMC6503982 | biostudies-literature
TranscriptomicsGEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program
Multiciliated cells (MCCs) project dozens to hundreds of motile cilia from their apical surface to promote the movement of fluids or gametes in the mammalian brain, airway or reproductive organs. Differentiation of MCCs requires the sequential action of the Geminin family transcriptional activators,...
ORGANISM(S): Homo sapiens 
2023-02-27 | GSE161197 | GEO
GenomicsSingle-cell RNA-sequencing of Gmnc and Mcidas knockout primary mouse tracheal epithelial cells (mTECs)
Single-cell RNA-sequencing of Gmnc and Mcidas knockout primary mouse tracheal epithelial cells (mTECs)
PRJNA888139 | ENA
UnknownMcIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation
Not available
S-SCDT-10_1038-S44319-026-00697-5 | biostudies-other
TranscriptomicsDNA damage-p53/p21 response contributes to ependymal cell development
Multiciliated Ependymal Cells and Adult Neural Stem Cells are components of the adult neurogenic niche, essential for brain homeostasis. These cells share a common glial cell lineage regulated by the Geminin family members Geminin and GemC1/Mcidas. Ependymal precursors require GemC1/Mcidas expressio...
ORGANISM(S): Mus musculus 
2021-09-21 | GSE184397 | GEO
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