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TranscriptomicsH3K9me3 Cut&Tag on hematopoietic stem cells sorted from mice 1 month after they were irradiated (2Gy total body irradiation = IR) or not (non irradiated = NIR) and with or without prior TNFa treatment (IR_TNF)
Analysis of the RNA-seq data performed in IR vs NIR hematopoietic stem cells show the loss of the TNF_via_NFKB signature. We showed that the loss of this signature could be associated with H3K9me3 loss at specific retrotransposable elements . To validate this association, we tested if TNFa treatment...
ORGANISM(S): Mus musculus 
2022-06-24 | E-MTAB-11864 | biostudies-arrayexpress
TranscriptomicsRNA-seq on hematopoietic stem cells sorted from mice 1 month after they were irradiated (2Gy total body irradiation = IR) or not (non irradiated = NIR)
We aim at understanding how ionizing radiations (IR) increase the risk of developing myeloid leukemia. We recently showed that IR leads to the derepression of retroelements. Retroelements are major contributors of gene regulatory networks. However, the impact of retroelements derepression on the HSC...
ORGANISM(S): Mus musculus 
2022-06-24 | E-MTAB-11866 | biostudies-arrayexpress
GenomicsH3K9me3 ChIP-seq on hematopoietic stem cells sorted from mice 1 month after they were irradiated (2Gy total body irradiation = IR) or not (non irradiated = NIR)
We aim at understanding how ionizing radiations (IR) increase the risk of developing myeloid leukemia. We recently showed that IR leads to the derepression of retroelements. We demonstrated that retroelements expression in aged HSCs is regulated by the heterochromatin repressive histone mark H3K9me3...
ORGANISM(S): Mus musculus 
2022-06-24 | E-MTAB-11865 | biostudies-arrayexpress
ProteomicsDevelopmental programming of Kupffer cells by maternal obesity causes fatty liver disease in the offspring
Kupffer cells (KCs) are tissue-resident macrophages which colonize the liver early during embryogenesis. KCs start to acquire a tissue-specific transcriptional signature immediately after colonizing the liver, mature together with the tissue, and adapt to the tissue?s functions. Throughout developme...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-01 | PXD058285 | Pride
Kupffer cells Fatty liver Mouse Maternal obesity 
TranscriptomicsDifferentiation and specification of resident tissue macrophages [ID3-KO RNA-seq]
Tissue resident macrophages are functionally diverse cells that share an embryonic mesodermal origin. However, the mechanism(s) that control their specification remain unclear. We performed transcriptional, molecular and in situ spatio-temporal analyses of macrophage development in mice. We report t...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-83854 | biostudies-arrayexpress
TranscriptomicsDifferentiation and specification of resident tissue macrophages [SMART-Seq2]
Tissue resident macrophages are functionally diverse cells that share an embryonic mesodermal origin. However, the mechanism(s) that control their specification remain unclear. We performed transcriptional, molecular and in situ spatio-temporal analyses of macrophage development in mice. We report t...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-81686 | biostudies-arrayexpress
TranscriptomicsDifferentiation and specification of resident tissue macrophages [MARS-seq]
Tissue resident macrophages are functionally diverse cells that share an embryonic mesodermal origin. However, the mechanism(s) that control their specification remain unclear. We performed transcriptional, molecular and in situ spatio-temporal analyses of macrophage development in mice. We report t...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-81760 | biostudies-arrayexpress
UnknownCirculating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults.
Not available
S-EPMC9381449 | biostudies-literature
ProteomicsLower H2S-generating enzyme levels and persulfidation-mediated protein protection characterize metabolic dysfunction-associated steatohepatitis
Metabolic dysfunction–associated steatohepatitis (MASH), marked by hepatic steatosis and inflammation, is a major risk for cirrhosis and liver cancer. Obesity-induced oxidative stress plays a central role in MASH promoting protein damage and dysfunction. Cysteine persulfidation (PSSH), a post-transl...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD057932 | Pride
Phosphoproteomics Cxcr4 oligomerization Apoptosis Lc-ms/ms 
ProteomicsMetabolic dysfunction-associated steatohepatitis reduces hepatic H2S- producing enzymes altering persulfidome composition
Metabolic dysfunction–associated steatohepatitis (MASH) is a progressive disease driven byobesity-related hepatic inflammation and oxidative stress. Recently, cysteine persulfidation (PSSH), a protective post-translational modification by hydrogen sulfide (H2S), was established to play a role in red...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD066952 | Pride
Persulfidome Obesity Mash 
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