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ProteomicsMultiomics approaches in Alexander disease zebrafish model show correlation between GFAP aggregation, altered lipid metabolism and oxidative stress
In this work we used our zebrafish model of Alexander Desease (AxD), aiming at unraveling the main pathways involved in AxD pathogenesis performing the first multi-omics analysis on a in vivo model of AxD. The obtained results have been functionally validated and they open the way to further investi...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-03-03 | PXD040214 | Pride
P.r239c mutation Danio rerio Alexander disease Gfap Zebrafish 
GenomicsGenome-wide DNA methylation analysis reveals dynamic changes in the cardiac methylome during post-natal heart development (MBD-Seq)
Epigenetic modifications have emerged as central players in the coordination of gene expression networks during cardiac development. While several studies have investigated the role of histone modifications during heart development, relatively little is known about the role of DNA methylation. The p...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-59969 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation analysis reveals dynamic changes in the cardiac methylome during post-natal heart development (RNA-Seq)
Epigenetic modifications have emerged as central players in the coordination of gene expression networks during cardiac development. While several studies have investigated the role of histone modifications during heart development, relatively little is known about the role of DNA methylation. The p...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-59970 | biostudies-arrayexpress
TranscriptomicsARTs versus developmental plasticity: blastocyst abnormalities after ICSI and embryo culture do not propagate into the offspring in mice
Following intracytoplasmic sperm injection (ICSI), in vitro culture (IVC) in ART media causes imbalance in the blastocyst's inner cell mass (ICM)with reduction of the primitive endoderm compartment compared to non-IVC blastocystsFollowing embryo transfer (ET), these imbalances do not influence birth...
ORGANISM(S): Mus musculus 
2016-08-25 | E-GEOD-50193 | biostudies-arrayexpress
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