Sort   by:  
 Page size 
MetabolomicsEffect of NAC154 transcription factor overexpression on the field grown poplar stem wood metabolome
Several xylem-associated regulatory genes have been identified that control processes associated with wood formation in poplar. Prominent among these are the NAC domain transcription factors (NACs). We evaluated the putative involvement of Populus NAC154, a co-ortholog of the Arabidopsis gene SND2, ...
2015-01-31 | MTBLS119 | MetaboLights
TranscriptomicsTranscription factor cooperativity in early adipogenic hotspots and super-enhancers
Here we have used a combination of advanced proteomics and genomics approaches to investigate the extent and mechanisms of transcription factor cross-talk at genomic hotspots. We identify ~12,000 transcription factor hotspots in the early phase of adipogenesis, and we find evidence of both simultane...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-56872 | biostudies-arrayexpress
GenomicsDNA selection by the master transcription factor PU.1
DNA selection by the master transcription factor PU.1
PRJNA870593 | ENA
ProteomicsThe hematopoietic master transcription factor PU.1 requires its interaction with the SWI/SNF remodeler to access chromatin de novo
PU.1 is a prototype master transcription factor (TF) of hematopoietic cell differentiation with diverse roles in different lineages. Analysis of its genome-wide binding pattern across PU.1 expressing cell types revealed manifold cell type-specific binding patterns. They are not consistent with the e...
ORGANISM(S): Homo sapiens (Human) 
2019-11-20 | PXD013167 | Pride
Chromatin remodelling Transcription factor Cell differenciation 
GenomicsAutophagy driven by a master regulator of hematopoiesis
Developmental and homeostatic remodeling of cellular organelles is mediated by a complex process termed autophagy. The cohort of proteins that constitute the autophagy machinery function in a multistep biochemical pathway. Though components of the autophagy machinery are broadly expressed, autophagy...
ORGANISM(S): Homo sapiens 
2011-09-30 | E-GEOD-32491 | biostudies-arrayexpress
GenomicsHistone methylation and transcription factor binding during intestinal cell differentation
Cell differentiation requires epigenetic modulation of tissue-specific genes and activities of master transcriptional regulators, which are recognized for their dominant control over cellular programs. Using novel epigenomic methods, we characterized enhancer elements specifically modified in differ...
ORGANISM(S): Mus musculus 
2010-11-17 | E-GEOD-23436 | biostudies-arrayexpress
ProteomicsFunctional analysis of Salix purpurea genes support roles for ARR17 and GATA15 as master regulators of sex determination
The Salicaceae family is of growing interest in the study of dioecy in plants because the sex determination region (SDR) has been shown to be highly dynamic, with differing locations and heterogametic systems across taxa. Previous studies investigating the mechanisms regulating sex in the genus Sali...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2023-02-01 | MSV000091180 | MassIVE
ProteomicsIdentification of RIOK2 as a master regulator of human blood cell development
Myelodysplastic syndromes (MDS) are a group of hematologic neoplasms in which the bone marrow fails to produce enough mature blood cells, leading to peripheral blood cytopenias and myeloproliferation1-3. The average survival time following diagnosis of MDS is 2.5 years4, owing to few treatment optio...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-16 | MSV000088238 | MassIVE
ProteomicsPBRM1 loss in kidney cancer imbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation
PBRM1 is the 2nd-most frequently inactivated gene in clear cell renal cell cancer (RCC) but the oncogenic mechanisms, and hence methods for correction, are unclear. PBRM1 is a subunit of the PBAF coactivator complex that transcription factors use to reposition nucleosomes (‘open chromatin’) for gene...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD020544 | Pride
Pbrm1 pax8 differentiation 
MetabolomicsPhosphoproteomic and Metabolomic Profiling Uncovers the Roles of CcPmk1 in the Pathogenicity of Cytospora chrysosperma

Pmk1, a highly conserved pathogenicity-related mitogen-activated protein kinase (MAPK) in pathogenic fungi, is phosphorylated and activated by MAP2K and acts as a global regulator of fungal infection and invasive growth by modulating downstream targets. However, the hierarchical CcPmk1 regulatory...

2022-07-11 | MTBLS4463 | MetaboLights
Sort   by:  
 Page size