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ProteomicsA cell cycle kinase-phosphatase module restrains PI3K- Akt activity in an mTORC1-dependent manner
The AKT-mTOR pathway is a central regulator of cell growth and metabolism. Upon sustained mTOR activity, AKT activity is attenuated by a feedback loop that restrains upstream signaling. However, how cells control the signals that limit AKT activity is not fully understood. Here we show that MASTL/Gr...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-11-23 | PXD032796 | Pride
Mastl Phosphosites Mouse Human 
ProteomicsMicrotubule-associated serine/threonine-protein kinase-like (MASTL) surfaceome proteomics analysis
Microtubule-associated serine/threonine-protein kinase-like (MASTL; a.k.a. Greatwall (Gwl) kinase) has an established role in the acceleration of cell cycle progression through inhibition of the PP2A-B55 phosphatase activity. Importantly, MASTL has emerged as a putative oncogene. Especially in breas...
ORGANISM(S): Homo sapiens (Human) 
2022-06-28 | PXD019993 | Pride
Breast cancer Cell contractility Cell migration Silac Surfaceome proteomics Mastl Cell adhesion 
ProteomicsProteome of Human breast cancer cell line (MDA-MB-231) with sileced MASTL vs NT control
MASTL (Microtubule associated serine-threonine kinase-like) is a relatively recently identified mitotic accelerator. There are also indications of its role in cancer progression, especially in breast cancer, but the molecular mechanisms behind this and the cell cycle independent functions of MASTL a...
ORGANISM(S): Homo sapiens (Human) 
2020-04-14 | PXD013757 | Pride
Breast cancer Cell contractility Cell migration Silac Mastl Cell adhesion 
UnknownMASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe.
Not available
S-EPMC12861094 | biostudies-literature
UnknownMASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels.
Not available
S-EPMC9167974 | biostudies-literature
UnknownThe MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner.
Not available
S-EPMC9841333 | biostudies-literature
ProteomicsChromosomal instability adaptation dependencies confer unique targetable vulnerabilities in therapy refractory lethal prostate cancer
Chromosomal instability (CIN), an ongoing rate of chromosome missegregation during mitosis, is a defining feature of cancer. However, high chromosomal aberrations are detrimental for cell fitness. Here we investigated mechanisms allowing lethal prostate cancer (PCa) to tolerate and survive increasin...
ORGANISM(S): Homo sapiens (Human) 
2023-01-14 | PXD028271 | Pride
Mastl expression Chromosomal instability 
UnknownDeficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos.
Not available
S-EPMC10964716 | biostudies-literature
ModelsAurora Kinase A in Neuroblastoma
Aurora Kinase A (AURKA) is often overexpressed in neuroblastoma (NB) with poor outcome. The causes of AURKA overexpression in NB are unknown. Here, we describe a gene regulatory network consisting of core regulators of AURKA protein expression and activation during mitosis to identify potential caus...
7916 | Cell Collective
UnknownThe MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner
Not available
S-SCDT-10_15252-EMBJ_2022110833 | biostudies-other
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