Sort   by:  
 Page size 
TranscriptomicsMAT2A promotes reprogramming of the androgen response pathway in association with ERG and EZH2
To date there are very few tools to reverse the induced dedifferentiation program in CRPC and to improve the response to the androgen deprivation therapy. Here we report that MAT2A is an important oncogenic cofactor of ERG/EZH2 transcriptional reprogramming impacting significantly the androgenic pat...
ORGANISM(S): Homo sapiens 
2023-07-15 | E-MTAB-12029 | biostudies-arrayexpress
ProteomicsTGF-β1/p65/MAT2A: a novel pathway involved in the regulation of intracellular SAM and liver fibrogenesis - Part2
Hepatic stellate cell (HSC) activation induced by transforming growth factor β (TGF-β1) plays a pivotal role in the fibrogenesis. The complex downstream mediators of TGF-β1 are largely unknown. Here, proteomics analysis and biological validation demonstrated that methionine adenosyltransferase 2A (M...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD011135 | Pride
Proteomics liver fibrosis mat2a 
ProteomicsTGF-β1/p65/MAT2A: a novel pathway involved in the regulation of intracellular SAM and liver fibrogenesis - Part1
Hepatic stellate cell (HSC) activation induced by transforming growth factor β (TGF-β1) plays a pivotal role in the fibrogenesis. The complex downstream mediators of TGF-β1 are largely unknown. Here, proteomics analysis and biological validation demonstrated that methionine adenosyltransferase 2A (M...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD011134 | Pride
Proteomics liver fibrosis  mat2a 
ProteomicsEpigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer
Castration-resistant prostate cancer (CRPC) is a frequently occurring disease with adverse clinical outcomes and limited therapeutic options. Here, we identify a novel role of methionine adenosyltransferase 2a (MAT2A) as a driver of the androgen-indifferent state in ERG fusion-positive CRPC. We show...
ORGANISM(S): Homo sapiens (Human) 
2024-06-06 | PXD042895 | Pride
Androgen-indifferent state Castration-resistant prostate cancer Mat2a Erg Epigenomics 
GenomicsMAT2A inhibitor in cancer cell lines
MAT2A inhibitor in cancer cell lines
PRJNA679231 | ENA
GenomicsMAT2A and methionine dependency are indispensible for H3K27M mutant gliomas.
MAT2A and methionine dependency are indispensible for H3K27M mutant gliomas.
PRJNA671595 | ENA
GenomicsMAT2A inhibition remodels H3K4me2/3 chromatin landscape in PDAC cells
MAT2A inhibition remodels H3K4me2/3 chromatin landscape in PDAC cells
PRJNA1494392 | ENA
GenomicsMAT2A as key regulator and therapeutic target in MLL leukemogenesis
MAT2A as key regulator and therapeutic target in MLL leukemogenesis
PRJNA594944 | ENA
UnknownInhibition of MAT2A Impairs Skeletal Muscle Repair Function.
Not available
S-EPMC11430595 | biostudies-literature
TranscriptomicsMAT2A promotes reprogramming of the androgen response pathway in association with ERG and EZH2
To date there are very few tools to reverse the induced dedifferentiation program in CRPC and to improve the response to the androgen deprivation therapy. Here we report that MAT2A is an important oncogenic cofactor of ERG/EZH2 transcriptional reprogramming impacting significantly the androgenic pat...
ORGANISM(S): Homo sapiens 
2023-08-07 | E-MTAB-12536 | biostudies-arrayexpress
Sort   by:  
 Page size