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TranscriptomicsEIF4E AND EIF4GI HAVE DISTINCT AND DIFFERENTIAL IMPRINTS ON MULTIPLE MYELOMA'S PROTEOME AND SIGNALING
Accumulating data indicate translation plays a role in cancer biology, particularly its rate limiting stage of initiation. Despite this evolving recognition, the function and importance of specific translation initiation factors is unresolved. The eukaryotic translation initiation complex eIF4F cons...
ORGANISM(S): Homo sapiens 
2015-10-29 | E-GEOD-62821 | biostudies-arrayexpress
UnknownProtein Abundance Biases the Amino Acid Composition of Disordered Regions to Minimize Non-functional Interactions.
Not available
S-EPMC6941228 | biostudies-literature
ProteomicsYeast Heatshock SILAC LC-MSMS
Yeast cells were incubated at 25˚C, unless otherwise stated. For SILAC, cells were grown in light labeled (0.03mg/ml Lys0, 0.02mg/ml Arg0) or heavy labeled (0.03mg/ml Lys4, 0.02mg/ml Arg6) amino acid in synthetic defined medium with 2% dextrose for at least 7 generations. heat shock was performed i...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-06-12 | PXD012631 | Pride
Stress granule Yeast Heatshock 
UnknownAgent-based modeling for personalized prediction of an experimental immune response to immunotherapeutic antibodies.
Not available
S-EPMC12148075 | biostudies-literature
UnknownInhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity.
Not available
S-EPMC8903836 | biostudies-literature
TranscriptomicsAttenuation of EIF4E Translation Initiation Adversely Affects Multiple Myeloma Cells
This work explores the therapeutic potential for the translation initiation factor eIF4E in multiple myeloma (MM). We show that targeting eIF4E is deleterious to MM cells and causes reduction of targets with established importance to the disease progression. We demonstrate that eIF4E inhibition may ...
ORGANISM(S): Homo sapiens 
2011-03-11 | E-GEOD-27897 | biostudies-arrayexpress
UnknownConsiderations for reporting variants in novel candidate genes identified during clinical genomic testing.
Not available
S-EPMC11456385 | biostudies-literature
UnknownBeyond the exome: What's next in diagnostic testing for Mendelian conditions.
Not available
S-EPMC10432150 | biostudies-literature
UnknownThe Effects of Cinacalcet in Older and Younger Patients on Hemodialysis: The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial.
Not available
S-EPMC4422239 | biostudies-literature
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