Sort   by:  
 Page size 
MetabolomicsGut Microbiota Mediates Maternal PM2.5 Exposure-induced Neurodevelopmental Disorder in offspring via Disturbing the Glutamate Metabolism: Evidence from Multiomics Analysis

While accumulating evidence links maternal PM2.5 exposure to offspring neurodevelopmental impairments, yet the underlying biological pathways require further elucidation. To address this, female ICR mice are exposed to filtered air (FA) or concentrated ambient particulate matter (CAP) for three ...

2026-01-05 | MTBLS13599 | MetaboLights
MetabolomicsMaternal steroids during pregnancy and their associations with ambient air pollution and temperature during preconception and early gestational periods
Hormones play critical roles in facilitating pregnancy progression and the onset of parturition. Several classes of environmental contaminants, including fine particulate matter (PM2.5) and ambient temperature, have been shown to alter hormone biosynthesis or activity. However, epidemiolo...
2024-06-27 | MTBLS2245 | MetaboLights
MetabolomicsFaecalibaculum rodentium as a key player in combating maternal obesity-induced labor disorders

The global rise in maternal obesity increases the risk of adverse maternal and neonatal outcomes. This study demonstrates that both long- (12 weeks) and short-term (gestational) exposure to a high-fat diet (HFD) induces uterine labor disorders, elevates stillbirth rates, and alters gut microbiota...

2025-08-22 | MTBLS12877 | MetaboLights
TranscriptomicsRNA-seq of estrogen (E2) induced changes of mRNA expression in early pregnant Sus scrofa endometrium
Maternal exposure to estrogens can induce long-term adverse effects in the offspring. This may be mediated through alterations in the endometrium affecting embryo-maternal communication as early as the preimplantational phase. Thus, we analyzed the effects of gestational estradiol-17β (E2) exposure ...
ORGANISM(S): Sus scrofa 
2018-10-16 | E-MTAB-6242 | biostudies-arrayexpress
MetabolomicsAmniotic-fluid metabolomics identifies phospholipid remodeling as a metabolic signature of intrauterine exposure in pregnancies with polycystic ovary syndrome
Background: Polycystic ovary syndrome is associated with metabolic and hormonal disturbances during pregnancy, but whether these alterations are reflected in the fetal intrauterine exposure environment remains incompletely understood. This study aimed to identify polycystic ovary syndrome-related in...
2026-07-25 | MTBLS14946 | MetaboLights
MetabolomicsMaternal gut microbiome, pregnancy exposure to environmental contaminants, and child health outcomes: A pilot study exploring potential effect modifications by diet
Not available
ORGANISM(S): Homo sapiens 
ST001040 | MetabolomicsWorkbench
MetabolomicsPrenatal exposure to trace elements impacts mother-infant gut microbiome, metabolome and resistome during the first year of life

Infancy is a critical period for the colonization of the gut microbiome. However, xenobiotic effects on gut microbiome development in early life remain poorly understood. Here, we recruit 146 mother-infant pairs and collect stool samples at 3, 6, and 12 months after delivery for amplicon sequenci...

2025-05-02 | MTBLS11392 | MetaboLights
TranscriptomicsMaternal diabetes alters transcriptional programs in the developing embryo.
Exposure to maternal diabetes during pregnancy alters transcriptional profiles in the developing embryo. The enrichment, within the set of de-regulated genes, of those encoding transcriptional regulatory molecules provides support for the hypothesis that maternal diabetes affects specific developme...
ORGANISM(S): Mus musculus 
2012-09-25 | E-GEOD-41095 | biostudies-arrayexpress
TranscriptomicsMaternal exposure to a Western-style diet causes differences in microbiota composition and gene expression in the intestine of suckling mouse pups
During the last few decades, the long-lasting consequences of nutritional programming during the early phase of life have become increasingly evident, but the effects of maternal nutrition on the developing intestine are currently still relatively underexplored. In this study, we investigated in mic...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-72705 | biostudies-arrayexpress
TranscriptomicsRepeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects in maternal and fetal tissues
Chlorpyrifos oxon (CPO), the toxic metabolite of the organophosphorus (OP) insecticide chlorpyrifos, causes developmental neurotoxicity in humans and rodents. CPO is hydrolyzed by paraoxonase-1 (PON1), with protection determined by PON1 levels and the human Q192R polymorphism. To examine how the Q19...
ORGANISM(S): Mus musculus 
2014-08-04 | E-GEOD-58103 | biostudies-arrayexpress
Sort   by:  
 Page size