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MetabolomicsA Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring.

BACKGROUND & AIMS: Micronutrient deficiency (MND) (ie, lack of vitamins and minerals) during pregnancy is a major public health concern. Historically, studies have considered micronutrients in isolation; however, MNDs rarely occur alone. The impact of co-occurring MNDs on pu...

2024-10-18 | MTBLS3476 | MetaboLights
MetabolomicsMaternal regulation of biliary disease in neonates via gut microbial metabolites

Maternal seeding of the microbiome in neonates promotes a long-lasting biological footprint, but how it impacts disease susceptibility in early life remains unknown. We hypothesized that feeding butyrate to pregnant mice influences the newborn’s susceptibility to biliary atresia, a severe cholang...

2022-01-11 | MTBLS2171 | MetaboLights
MetabolomicsLimited vertical transmission but profound immune dysregulation at the maternal-fetal interface after SARS-CoV-2 infection

The endemic of SARS-CoV-2 underscores the imperative to elucidate its effects on pregnancy, particularly regarding the potential for vertical transmission and its influence on the early maternal-fetal interface, which remain insufficiently defined. To address this, we performed an extensive cohor...

2026-03-05 | MTBLS13103 | MetaboLights
MetabolomicsDysregulation of lipid metabolism and pathological inflammation in patients with COVID-19
In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-CoV-2 infec...
2023-02-01 | MTBLS6844 | MetaboLights
ProteomicsTargeting Saa expression via siRNA mitigates preterm birth induced by maternal inflammation
Introduction: Placental inflammation is a major contributor to preterm birth (PTB), and there are currently few targeted strategies to prevent PTB and its associated adverse neonatal outcomes. Serum amyloid A (SAA), particularly the isoforms SAA1 and SAA2, are well-recognized inflammatory markers, b...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD072875 | Pride
P2x7r-dependent signaling Raw264.7 cell line Saa2 Sirna-mediated targeting of saa2 
GenomicsMaternal Nutrition Induces Pervasive Gene Expression Changes but no Detectable DNA Methylation Differences in the Liver of Adult Offspring [RRBS]
Aims: Epidemiological and animal studies have shown that maternal diet can influence metabolism in adult offspring. However, the molecular mechanisms underlying these changes remain poorly understood. Here, we aim to explore phenotypes induced by maternal obesity in a mouse model and examine gene ex...
ORGANISM(S): Mus musculus 
2014-03-04 | E-GEOD-52266 | biostudies-arrayexpress
GenomicsMaternal Nutrition Induces Pervasive Gene Expression Changes but no Detectable DNA Methylation Differences in the Liver of Adult Offspring [selected loci]
Aims: Epidemiological and animal studies have shown that maternal diet can influence metabolism in adult offspring. However, the molecular mechanisms underlying these changes remain poorly understood. Here, we aim to explore phenotypes induced by maternal obesity in a mouse model and examine gene ex...
ORGANISM(S): Mus musculus 
2014-03-04 | E-GEOD-52267 | biostudies-arrayexpress
GenomicsFetal brain response to maternal inflammation requires microglia [Maternal_Inflammation]
Fetal brain response to maternal inflammation requires microglia [Maternal_Inflammation]
PRJNA935692 | ENA
GenomicsFetal brain response to maternal inflammation requires microglia [Developing_Microglia]
Fetal brain response to maternal inflammation requires microglia [Developing_Microglia]
PRJNA935748 | ENA
TranscriptomicsModulation of the immune system during postpartum uterine inflammation [expression]
Post-partum uterine inflammation (endometritis) is associated with lower fertility at both the time of infection and after the inflammation has resolved. It was hypothesized that aberrant DNA methylation may be involved in the sub-fertility associated with post-partum uterine inflammation. The objec...
ORGANISM(S): Bos taurus 
2015-05-07 | E-GEOD-58794 | biostudies-arrayexpress
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