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MetabolomicsFaecalibaculum rodentium as a key player in combating maternal obesity-induced labor disorders

The global rise in maternal obesity increases the risk of adverse maternal and neonatal outcomes. This study demonstrates that both long- (12 weeks) and short-term (gestational) exposure to a high-fat diet (HFD) induces uterine labor disorders, elevates stillbirth rates, and alters gut microbiota...

2025-08-22 | MTBLS12877 | MetaboLights
MetabolomicsHuman Milk-Derived 5′-UMP Promotes Thermogenesis and Mitochondrial Biogenesis to Ameliorate obesity

Background: Traditional obesity interventions are often unsuitable for children. Breastfeeding has been shown to reduce obesity risk, potentially through bioactive metabolites in human milk. Here, we identified a human milk-derived metabolite, uridine 5'-monophosphate (5'-UMP), whose role in lipi...

2025-09-23 | MTBLS13027 | MetaboLights
TranscriptomicsIdentification and Comparative Analyses of Myocardial miRNAs Involved in Fetal Response to Maternal Obesity
Maternal obesity programs the offspring to cardiovascular disease, insulin resistance, and obesity. We sequenced and profiled the cardiac miRNAs that were dysregulated in the hearts of baboon fetuses born to a high fat / high fructose diet fed mothers compared to a regular diet fed mothers. Fetal he...
ORGANISM(S): Papio hamadryas 
2013-02-01 | E-GEOD-43323 | biostudies-arrayexpress
MetabolomicsMaternal obesity alters offspring liver and skeletal muscle metabolism in early post-puberty despite maintaining a normal post-weaning dietary lifestyle
Not available
ORGANISM(S): Papio hamadryas 
ST002254 | MetabolomicsWorkbench
TranscriptomicsGene expression profile in offspring born before vs. after maternal bariatric surgery
Evaluate differences in gene expression levels between offspring born after maternal bariatric surgery and their siblings born before surgery Offspring born after maternal bariatric surgery (AMS, N=23) vs. offspring born before maternal surgery (BMS, N=23)
ORGANISM(S): Homo sapiens 
2013-05-16 | E-GEOD-44407 | biostudies-arrayexpress
MetabolomicsMetabolomics profile of umbilical cord blood is associated with maternal pre-pregnant obesity in a perspective multi-ethnic cohort displaying health disparities
Not available
ORGANISM(S): Homo sapiens 
ST001114 | MetabolomicsWorkbench
ProteomicsThe Role of Maternal Obesity in Offspring Cardiovascular Development and Congenital Heart Defects
Background: Congenital heart disease (CHD) is a leading cause of death in newborns, yet many of its molecular mechanisms remain unknown. Both maternal obesity and diabetes increase the risk of CHD in offspring, with recent studies suggesting these conditions may have distinct teratogenic mechanisms....
ORGANISM(S): Mus musculus (Mouse) 
2025-06-30 | PXD062087 | Pride
Cardiac development Congenital heart disease Gene-environment interaction Maternal obesity 
TranscriptomicsInvestigation of placental gene expression in obese women exposed to Metformin during pregnancy
Maternal obesity in pregnancy is associated with increased birth-weight, obesity and premature mortality in adult offspring. The Effect of Metformin on Maternal and Fetal Outcomes in Pregnant Obese Women (EMPOWaR) trial was a randomised, double-blind, placebo-controlled trial carried out to determin...
ORGANISM(S): Homo sapiens 
2019-01-31 | E-MTAB-6418 | biostudies-arrayexpress
TranscriptomicsInvestigation of placental DNA methylation in obese women exposed to Metformin during pregnancy
Maternal obesity in pregnancy is associated with increased birth-weight, obesity and premature mortality in adult offspring. The Effect of Metformin on Maternal and Fetal Outcomes in Pregnant Obese Women (EMPOWaR) trial was a randomised, double-blind, placebo-controlled trial carried out to determin...
ORGANISM(S): Homo sapiens 
2018-11-01 | E-MTAB-6421 | biostudies-arrayexpress
TranscriptomicsEffect of perinatal obesity on premature kidney aging signaling
Chronic Kidney Disease (CKD), a global health burden, is strongly associated with age-related renal function decline, hypertension and diabetes, frequent consequences of obesity. Despite extensive studies the mechanisms determining susceptibility to CKD remain elusive. Clinical evidence together wit...
ORGANISM(S): Mus musculus 
2022-12-31 | E-MTAB-10954 | biostudies-arrayexpress
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