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MetabolomicsEffect of Genetically Reduced Maternal Myostatin on Late Gestation Maternal, Fetal, and Placental Metabolomes in Mice.
Myostatin (gene symbol: Mstn) is an autocrine and paracrine inhibitor of muscle growth. Pregnant mice with genetically reduced levels of myostatin give birth to offspring with greater adult muscle mass and bone biomechanical strength. However, maternal myostatin is not detectable in fetal cir...
2023-06-08 | MTBLS3345 | MetaboLights
MetabolomicsMaternal steroids during pregnancy and their associations with ambient air pollution and temperature during preconception and early gestational periods
Hormones play critical roles in facilitating pregnancy progression and the onset of parturition. Several classes of environmental contaminants, including fine particulate matter (PM2.5) and ambient temperature, have been shown to alter hormone biosynthesis or activity. However, epidemiolo...
2024-06-27 | MTBLS2245 | MetaboLights
MetabolomicsMaternal lipid mobilization is essential for embryonic development in a key malaria vector
Lipid metabolism is an essential component in reproductive physiology. While lipid mobilization has been implicated in the growth of Plasmodium falciparum malaria parasites in their Anopheles vectors, the role of this process in the reproductive biology of these mosquitoes remains elusive. Here, we ...
2024-11-05 | MTBLS9881 | MetaboLights
MetabolomicsA Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring.

BACKGROUND & AIMS: Micronutrient deficiency (MND) (ie, lack of vitamins and minerals) during pregnancy is a major public health concern. Historically, studies have considered micronutrients in isolation; however, MNDs rarely occur alone. The impact of co-occurring MNDs on pu...

2024-10-18 | MTBLS3476 | MetaboLights
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - Smartseq 2 data
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. This part contains RN...
ORGANISM(S): Homo sapiens 
2019-08-21 | E-MTAB-6678 | biostudies-arrayexpress
TranscriptomicsAssociation of maternal mRNA with the spindle in mouse oocytes
The oocytes of many species, both invertebrate and vertebrate, contain a large collection of localized determinants in the form of proteins and translationally inactive maternal mRNAs. However, it is unknown whether mouse oocytes contain localized MmRNA determinants and what mechanisms might be resp...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-46875 | biostudies-arrayexpress
ProteomicsLSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance
Fully grown oocytes remain transcriptionally quiescent, yet many maternal mRNAs are synthesized and retained in growing oocytes. We now know that maternal mRNAs are stored in a structure called the mitochondria associated ribonucleoprotein domain (MARDO). But the components and functions of MARDO re...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-17 | PXD042761 | Pride
Lsm14b  oocyte meiotic maturation  mrna storage 
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - whole genome sequencing
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. Demuxlet was used to ...
ORGANISM(S): Homo sapiens 
2018-10-17 | E-MTAB-7304 | biostudies-arrayexpress
TranscriptomicsThe knockdown of the maternal estrogen receptor-β2 mRNA (ers2a) affects embryo transcript contents and larval development in zebrafish
In zebrafish, vitellogenic oocytes can incorporate significant amounts of 17β-estradiol released from nearby granulosa cells according to a first-order kinetics, since the steroid low polarity ensures high permeability and affinity for yolk lipids. Estrogen bioactivity is likely, because the materna...
ORGANISM(S): Danio rerio 
2011-01-12 | E-GEOD-24934 | biostudies-arrayexpress
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - 10x data
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. RNA-seq was done usin...
ORGANISM(S): Homo sapiens 
2018-10-02 | E-MTAB-6701 | biostudies-arrayexpress
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