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ProteomicsProtein abundance of AKT and ERK pathway components governs cell-type-specific regulation of proliferation
Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involving signal processing, cell growth and cell-cycle progression, is poorly understood. Here we study different murine hematopoietic cell types, in which AKT and E...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080844 | MassIVE
TranscriptomicsPrimary breast tumor-derived cellular models: characterization of tumorigenic, metastatic, and cancer-associated fibroblasts in dissociated tumor (DT) cultures
The study of breast cancer pathogenesis relies heavily on the use of established cell lines often derived from metastatic lesions, which while having significantly contributed to the knowledge of breast cancer biology may inadvertently limit the understanding of the mechanisms governing the metastat...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-55070 | biostudies-arrayexpress
TranscriptomicsGene expression data for two xenograft models representing luminal-like and basal-like breast cancer
Choline (reference 1) and glucose (reference 2) was studied using HR MAS MR spectroscopy data and 105 and 38 gene transcripts were selected respectively from the microarray data to study differences between two xenograft models. Reference 1: Moestue SA et al, Distinct choline metabolic profiles are ...
ORGANISM(S): Homo sapiens 
2010-12-08 | E-GEOD-25915 | biostudies-arrayexpress
TranscriptomicsDysregulated expression and alternative splicing of genes controlling neuritogenesis and axon guidance revealed by exon-sensitive microarrays in models of neurodegeneration
This SuperSeries is composed of the following subset Series: GSE21298: Profiling wt SOD versus ALS SOD1(G93A) mutant GSE21305: Profiling neuroblastoma SH-SY5Y with Paraquat treatment Mitochondrial dysfunction has been directly or indirectly implicated in the pathogenesis of a number of neurodegener...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-21450 | biostudies-arrayexpress
ModelsProctor2010 - UCHL1 Protein Aggregation
This a model from the article: Modelling the Role of UCH-L1 on Protein Aggregation in Age-Related Neurodegeneration. Proctor CJ, Tangeman PJ, Ardley HC. PLoS One. 2010 Oct 6;5(10):e13175 20949132 , A...
2024-09-02 | BIOMD0000000293 | BioModels
TranscriptomicsGenomic profile of foamy and non-foamy granuloma macrophages from fat-fed ApoE null mice or control mice fed a normal diet
Formation of foam cell macrophages (FCMs), which sequester extracellular modified lipids, is a key event in atherosclerosis. How lipid loading affects macrophage phenotype is controversial, with evidence suggesting either pro- or anti-inflammatory consequences. To investigate this further, we compar...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-70126 | biostudies-arrayexpress
ProteomicsOverexpression of the plastidial pseudo-protease AtFtsHi3 enhances drought tolerance while sustaining plant growth
With climate change, droughts are expected to be more frequent and severe, severely impacting plant biomass and quality. Here, we show that overexpressing the Arabidopsis gene AtFtsHi3 (FtsHi3OE) enhances drought-tolerant phenotypes without compromising plant growth. AtFtsHi3 encodes a chloroplast e...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-06-14 | PXD037172 | Pride
Lc-ms/ms based proteomics Pseudo-protease ftshi3 Drought tolerance Mathematical models of protein complex formation 
TranscriptomicsEvaluation of methods for modeling transcription factor sequence specificity
Genomic analyses often involve scanning for potential transcription-factor (TF) binding sites using models of the sequence specificity of DNA binding proteins. Many approaches have been developed to model and learn a protein’s binding specificity by representing sequence motifs, including the gaps a...
ORGANISM(S): synthetic construct 
2012-12-13 | E-GEOD-42864 | biostudies-arrayexpress
TranscriptomicsGenome-wide time series analysis of gastrin induced gene expression in AR42J cells with and without protein synthesis
Genome-wide gene expression time series experiments are an important approach to studying a cells response to a given stimulus, as they enable capturing of the dynamics of the response. Moreover, information about the dynamics of the system is an important prerequisite for inferences on interactions...
ORGANISM(S): Rattus norvegicus 
2011-10-16 | E-GEOD-32869 | biostudies-arrayexpress
UnknownTopological Data Analysis Approaches to Uncovering the Timing of Ring Structure Onset in Filamentous Networks.
Not available
S-EPMC7811524 | biostudies-literature
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