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TranscriptomicsThe matricellular protein CCN1 activates a pro-inflammatory genetic program in murine macrophages
Effects of the matricellular protein CCN1 on macrophage inflammatory gene expression was tested in a macrophage cell line I-13.35. CCN1 (CYR61) is a matricellular protein that is highly expressed at sites of inflammation and wound repair. In these contexts, CCN1 can modify the activities of specifi...
ORGANISM(S): Mus musculus 
2010-05-14 | E-GEOD-19731 | biostudies-arrayexpress
ProteomicsA 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in cancer
The remodeling of the extracellular matrix (ECM) by proteases releases fragments that promote tumor progression and metastasis. The protease cathepsin D (cath-D), a marker of poor prognosis in triple-negative breast cancer (TNBC), is aberrantly secreted in the ECM. Using degradomics, we discovered t...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022826 | Pride
Ecm Tnbc Protease Proteolysis Matricellular protein Tumor microenvironment 
GenomicsThe matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
PRJNA705658 | ENA
GenomicsThe matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner
The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner
PRJNA601160 | ENA
GenomicsThe matricellular protein Connective Tissue Growth Factor promotes motor axon regeneration
The matricellular protein Connective Tissue Growth Factor promotes motor axon regeneration
PRJNA646639 | ENA
GenomicsCancer-associated fibroblast-specific expression of the matricellular protein CCN1 coordinates neovascularization and stroma deposition in melanoma metastasis
Cancer-associated fibroblast-specific expression of the matricellular protein CCN1 coordinates neovascularization and stroma deposition in melanoma metastasis
PRJNA1065877 | ENA
UnknownTracheal Aspirate Levels of the Matricellular Protein SPARC Predict Development of Bronchopulmonary Dysplasia.
Not available
S-EPMC4676701 | biostudies-literature
UnknownThe Matricellular Protein Hevin Is Involved in Alcohol Use Disorder.
Not available
S-EPMC9953008 | biostudies-literature
UnknownSCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity.
Not available
S-EPMC8487547 | biostudies-literature
TranscriptomicsThe matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
SPARC is a member of matricellular protein, and emerging evidence suggests that it plays a critical role in integrated metabolic and inflammatory responses. However, the mechanism how SPARC activates inflammation is still unanswered. Here we showed that excess SPARC induced sterile inflammation, and...
ORGANISM(S): Mus musculus 
2022-08-12 | GSE167950 | GEO
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