Matrix mineralization

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GPM6B regulates osteoblast differentiation and induction of mineralization by controlling cytoskeleton and matrix vesicle release.

Analysis of GPM6B silenced osteogenic hMSC at gene expression level. Analysis is showing significant changes in genes involved in cytoskeleton organization and biogenesis. Immunocytochemistry confirms changed distribution of actin filaments and change in shape and in size of focal adhesions upon GP...

ORGANISM(S): Homo sapiens

2011-06-01 | E-GEOD-26004 | biostudies-arrayexpress

Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone

We used gene array analysis of cortical bone to identify Phex-dependent gene transcripts regulating Fgf23 production and mineralization in Hyp mice. We discovered that activation of Fgf receptor- and Wnt-pathways contribute to increased Ffg23 gene transcription in Hyp bone. We found evidence in Hyp ...

ORGANISM(S): Mus musculus

2009-12-21 | E-GEOD-14242 | biostudies-arrayexpress

Matrix mineralization controls gene expression in osteoblasts

PRJNA470642 | ENA

Plant-derived soybean peroxidase stimulates osteoblast collagen biosynthesis and matrix mineralization

PRJNA706780 | ENA

Matrix mineralization controls gene expression in osteoblasts

Osteoblasts are adherent cells. Under physiological conditions they attach to mineralized and non-mineralized osseous surfaces. However, how exactly osteoblasts respond to these different osseous surfaces is largely unknown. Our hypothesis was that the state of matrix mineralization provides a funct...

ORGANISM(S): Homo sapiens

2018-09-30 | GSE114237 | GEO

Phosphate induces formation of matrix vesicles during odontoblast-initiated mineralization in vitro.

Not available

S-EPMC4875887 | biostudies-literature

Long non-coding RNA CASC2 regulates osteoblasts matrix mineralization

Long non-coding RNAs (lncRNAs) are master regulators of gene expression and have recently emerged as potential innovative therapeutic targets. The deregulation of lncRNA expression patterns has been associated with age-related and noncommunicable diseases, including osteoporosis and bone tumors. How...

ORGANISM(S): Homo sapiens (Human)

2023-06-14 | PXD040463 | Pride

Ectopic mineralization disorders of the extracellular matrix of connective tissue: molecular genetics and pathomechanisms of aberrant calcification.

Not available

S-EPMC3902053 | biostudies-literature

Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts

Four and a half LIM domains protein 2 (FHL2) is a co-regulator of gene transcription relevant for many signalling pathways and physiological processes. In this work, the role of FHL2 in cell differentiation has been investigated during in vitro mineralization using a Sparus aurata pre-osteoblast cel...

ORGANISM(S): Sparus aurata

2013-01-03 | E-GEOD-32501 | biostudies-arrayexpress

Biomimetic mineralization using matrix vesicle nanofragments.

Not available

S-EPMC6594056 | biostudies-literature

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