MC3T3-E1 cells were divided into two groups: si-NC and si-Connexin43. Cx43 expression was knocked down using siRNA transfection, followed by LC–MS-based untargeted metabolomic analysis to investigate metabolic alterations associated with Connexin 43 deficiency in osteoblasts and its potential rol...
This study investigates the effect of Achyranthes bidentata polysaccharide-strontium (ABPS-Sr) chelate on tibial dyschondroplasia (TD) in broilers and its underlying mechanisms. TD is a prevalent leg disorder in commercial broilers characterized by reduced angiogenesis in the tibial growth plate ...
This study investigates the effect of Achyranthes bidentata polysaccharide-strontium (ABPS-Sr) chelate on tibial dyschondroplasia (TD) in broilers and its underlying mechanisms. TD is a prevalent leg disorder in commercial broilers characterized by reduced angiogenesis in the tibial growth plate ...
Chronic, drug-resistant bone infection caused by methicillin-resistant Staphylococcus aureus (MRSA) features an immunosuppressive niche enabling persistent infection and impaired bone healing. Specific treatment requires initial antibacterial immune activation against infection, followed by resha...
Bone regeneration requires spatiotemporal coordination of immune modulation, stem cell recruitment, angiogenesis, and osteogenesis, yet most scaffolds lack sequential control across healing phases. We develop a near-infrared (NIR)-responsive therapeutic platform that integrates clinically av...
Bone homeostasis mainly depends on the equilibrium of osteoclasts and osteoblasts, overactivated osteoclasts play a pivotal role in the progression of osteoporosis. Here, we revealed that Pla2g7 (phospholipase A2 group VII) was positively correlated with bone resorption in clinic. By single-cell ...
Bone metastasis is a lethal consequence of breast cancer. AT-rich interaction domain 1A gene (ARID1A), a subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, regulates immunosuppressive tumor microenvironment. ARID1A deficient triple negative breast cancer promotes bone metastasis.To ...
Emerging evidence suggests a significant role of gut microbiome in bone health. Aging is well recognized as a crucial factor influencing the gut microbiome. In this study, we investigated whether age-dependent microbial change contributes to age-related bone loss in CB6F1 mice. The bone phenotype...