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The nuclear scaffold/matrix provides an anchor for higher order genome structure that has both structural and functional implications. Different extraction protocols, i.e., utilizing either 25 mM LIS or 2 M NaCl, isolate somewhat different protein constituents of either the nuclear scaffold or nucl...
ORGANISM(S): Homo sapiens 
Scaffold or matrix attachment regions (S/MARs) are found in all eukaryotes. The pattern of distribution and genomic context of S/MARs is thought to be important for processes such as chromatin organization and modulation of gene expression. Despite the importance of such processes, much is unknown a...
ORGANISM(S): Arabidopsis thaliana 
We report the application of Chromosome Conformation Capture Carbon-copy (5C) to a 4.5 Mb stretch of the mouse X chromosome encompassing the X inactivation center locus. We uncover a series of discrete 200kb-1Mb topologically associating domains (TADs). These align with several domain-wide epigenomi...
ORGANISM(S): Mus musculus 
Across the spectrum of human disease there are significant changes in the composition and organisation of extracellular matrix (ECM). Furthermore, disease severity can vary according to race and sex, yet mechanisms for these variations are unclear. Using the kidney glomerulus as a model system, we t...
ORGANISM(S): Mus musculus (Mouse) 
2016-07-09 | PXD000811 | Pride
Integrated proteomic and glycoproteomic characterisation of the peritrophic matrix from L. cuprina larvae reared on distinct diets.
ORGANISM(S): Lucilia cuprina 
2026-08-31 | PXD069705 | Pride
Pancreatic ductal adenocarcinoma (PDAC) cells rely on glutamine to sustain their survival and growth in their stiff, hypoxic tumour microenvironment (TME). Inhibiting the glutamate oxaloacetate transaminase 1 (GOT1) enzyme is a promising strategy to target glutamine metabolism and impair PDAC cell f...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD065374 | Pride
Data from ProteomeXchange, PXD ID: PXD001450. File: 13-3105_Gautron_7h_1_ORBI486.mzML. Published as part of J Proteomics. 2015 Jun 3. pii: S1874-3919(15)30033-6 . From the Abstract: {{i}} Eggshell is a bioceramic composed of 95% calcium carbonate mineral and 3.5% organic matrix. Its structural orga...
ORGANISM(S): Chicken 
Analysis of GPM6B silenced osteogenic hMSC at gene expression level. Analysis is showing significant changes in genes involved in cytoskeleton organization and biogenesis. Immunocytochemistry confirms changed distribution of actin filaments and change in shape and in size of focal adhesions upon GP...
ORGANISM(S): Homo sapiens 
Three-dimensional imaging mass spectrometry (3D imaging MS) is a technique of analytical chemistry for 3D molecular analysis of a tissue specimen, entire organ, or microbial colonies on an agar plate. 3D imaging MS has unique advantages over existing 3D imaging techniques, offers novel perspectives ...
2016-07-27 | MTBLS176 | MetaboLights
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