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UnknownA Spatial Transcriptome Reveals Changes in Tumor and Tumor Microenvironment in Oral Cancer with Acquired Resistance to Immunotherapy.
Although anti-programmed death-1 (PD-1) antibody therapy improves the prognosis in patients with head and neck squamous cell carcinoma (HNSCC), some patients exhibit disease progression even after showing a good response to the treatment initially because of acquired resistance. Here, we aimed to re...
S-EPMC10742283 | biostudies-literature
UnknownGene expression pattern after insertion of dexamethasone-eluting electrode into the guinea pig cochlea.
A cochlear implant is an indispensable apparatus for a profound hearing loss patient. But insertion of the electrode entails a great deal of stress to the cochlea, and may cause irreversible damage to hair cells and related nerve structure. Although damage prevention effects of dexamethasone have be...
S-EPMC4203767 | biostudies-literature
UnknownA novel incision design for Vibrant SoundBridge® implantation prior to auricular reconstruction for microtia.

Objective

This study aimed to present and evaluate a surgical approach for placing a Vibrant Soundbridge® (VSB) device prior to auricular reconstruction in patients with microtia atresia. The goal was to determine whether an incision line for VSB implantation, located sufficiently posterior ...
S-EPMC12306728 | biostudies-literature
UnknownPrognostic significance of pre- and post-treatment hematological biomarkers in patients with head and neck cancer treated with chemoradiotherapy.
This study aimed to investigate the prognostic value of hematological biomarkers measured before and after treatment in patients with head and neck cancer (HNC). This study reviewed 124 patients with HNC who received chemoradiotherapy. Hematological biomarkers assessed before and after treatment wer...
S-EPMC9995483 | biostudies-literature
UnknownFailed Left Atrial Vent Insertion During Mitral Valve Surgery Due to Anomalous Unilateral Single Pulmonary Vein.

Background

Anomalous unilateral single pulmonary vein (AUSPV) is extremely rare and usually managed conservatively, requiring caution when accompanied by other heart diseases.

Case summary

A 73-year-old woman who presented with exertional dyspnea was diagnosed with severe mitral valve...
S-EPMC12665861 | biostudies-literature
UnknownA high-resolution physical map integrating an anchored chromosome with the BAC physical maps of wheat chromosome 6B.

Background

A complete genome sequence is an essential tool for the genetic improvement of wheat. Because the wheat genome is large, highly repetitive and complex due to its allohexaploid nature, the International Wheat Genome Sequencing Consortium (IWGSC) chose a strategy that involves const...
S-EPMC4534020 | biostudies-literature
UnknownImmunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.

Background

Mutations in the valosin-containing protein (VCP) gene were first found to cause inclusion- body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD). Mutations in the VCP gene were later reported to occur in familial amyotrophic lateral sclerosis (ALS). Bu...
S-EPMC4297454 | biostudies-literature
UnknownComprehensive analysis of syndromic hearing loss patients in Japan.
More than 400 syndromes associated with hearing loss and other symptoms have been described, corresponding to 30% of cases of hereditary hearing loss. In this study we aimed to clarify the mutation spectrum of syndromic hearing loss patients in Japan by using next-generation sequencing analysis with...
S-EPMC6700179 | biostudies-literature
UnknownLarge-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.
Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicated in patients with various neuropsychiatric disord...
S-EPMC10965225 | biostudies-literature
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