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UnknownMolecular classification of ovarian high-grade serous/endometrioid carcinomas through multi-omics analysis: JGOG3025-TR2 study.

Background

Considerable interobserver variability exists in diagnosis of ovarian high-grade endometrioid carcinoma (HGEC) and high-grade serous carcinoma (HGSC) due to histopathological similarities. While homologous recombination deficiency (HRD) correlates with drug sensitivity in HGSC, th...
S-EPMC11473812 | biostudies-literature
UnknownHomologous Recombination Deficiency Unrelated to Platinum and PARP Inhibitor Response in Cell Line Libraries.
While large publicly available cancer cell line databases are invaluable for preclinical drug discovery and biomarker development, the association between homologous recombination deficiency (HRD) and drug sensitivity in these resources remains unclear. In this study, we comprehensively analyzed mol...
S-EPMC10847511 | biostudies-literature
UnknownGenomic profile predicts the efficacy of neoadjuvant chemotherapy for cervical cancer patients.

Background

Neoadjuvant chemotherapy (NAC) using platinum and irinotecan (CPT-11) followed by radical excision has been shown to be a valid treatment for locally advanced squamous cervical cancer (SCC) patients. However, in NAC-resistant or NAC-toxic cases, surgical treatment or radiotherapy ...
S-EPMC4612400 | biostudies-literature
UnknownHomologous recombination deficiency status-based classification of high-grade serous ovarian carcinoma.
Homologous recombination repair (HRR) pathway deficiency (HRD) is involved in the tumorigenesis and progression of high-grade serous ovarian carcinoma (HGSOC) as well as in the sensitivity to platinum chemotherapy drugs. In this study, we obtained data from The Cancer Genome Atlas (TCGA) on HGSOC an...
S-EPMC7026096 | biostudies-literature
TranscriptomicsGene expression in human endometrial cancer tissues and serous papillary endometrial cancer cell line, SPAC-1L, treated by STAT1-siRNA and/or IFN-gamma
Endometrial cancer is one of the most common gynecologic malignancies, and patients with high grade disease, especially serous papillary subtype (SPEC) are often related to the poor outcomes. Recent genome-wide analyses have revealed that SPEC exhibits gene expression profiles that are distinct from...
ORGANISM(S): Homo sapiens 
2014-03-20 | E-GEOD-56026 | biostudies-arrayexpress
UnknownFrequent PIK3CA mutations in eutopic endometrium of patients with ovarian clear cell carcinoma.
Recent studies have reported cancer-associated mutations in normal endometrium. Mutations in eutopic endometrium may lead to endometriosis and endometriosis-associated ovarian cancer. We investigated PIK3CA mutations (PIK3CAm) for three hotspots (E542K, E545K, H1047R) in eutopic endometrium in patie...
S-EPMC8514336 | biostudies-literature
UnknownLack of molecular mimicry between HPV vaccine L1 antigen and human proteins by a computational analysis.

Background

Although human papillomavirus (HPV) vaccines effectively prevent cervical cancer, the HPV vaccination rates in Japan remain low because of concerns about alleged neurological adverse events. Darja Kanduc proposed a flawed hypothesis that molecular mimicry between HPV and human pro...
S-EPMC12932383 | biostudies-literature
UnknownAcquisition of a side population fraction augments malignant phenotype in ovarian cancer.
Side population (SP) cells harbor malignant phenotypes in cancer. The aim of this study was to identify genes that modulate the proportion of ovarian cancer SP cells. Using a shRNA library targeting 15,000 genes, a functional genomics screen was performed to identify genes whose suppression increase...
S-EPMC6775117 | biostudies-literature
TranscriptomicsExpression data from ovarian cancer cell lines
Ovarian clear cell carcinoma (OCCC) shows unique clinical features including an association with endometriosis and poor prognosis. We previously reported that the contents of endometriotic cysts, especially high concentrations of free iron, are a possible cause of OCCC carcinogenesis through iron-in...
ORGANISM(S): Homo sapiens 
2011-05-16 | E-GEOD-29175 | biostudies-arrayexpress
TranscriptomicsExpression data from cultured human ovarian carcinoma cell lines
The hallmark of human cancer is heterogeneity, mirroring the complexity of genetic and epigenetic alterations acquired during oncogenesis. We extracted RNA of 34 cultured human ovarian carcinoma cell lines and performed expression microarrays so that cultured cell lines can represent in vivo human ...
ORGANISM(S): Homo sapiens 
2013-05-21 | E-GEOD-28724 | biostudies-arrayexpress
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