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TranscriptomicsInfluence of DEN in mice liver
Hepatocellular carcinoma is the third leading cause of cancer death worldwide, and it is necessary to elucidate the mechanism of hepatocarcinogenesis. Hepatocellular carcinoma (HCC) has a high mortality rate and develops based on the chronic inflammatory hepatic disease. Therefore, novel prophylacti...
ORGANISM(S): Mus musculus 
2014-06-06 | E-GEOD-57798 | biostudies-arrayexpress
TranscriptomicsInfluence of retinol on kidney in 5/6 nephrectomy mice
The circadian clock has been found to be associated with various diseases. We showed that 5/6 nephrectomy (5/6Nx) Clk/Clk mice, which show mutation in the gene encoding circadian locomotor output cycles (Clock) do not show aggravation of renal fibrosis because transforming growth factor-1 (Tgf-1) ex...
ORGANISM(S): Mus musculus 
2014-06-06 | E-GEOD-57799 | biostudies-arrayexpress
TranscriptomicsInfluence of G0s2 gene knockdown on primary hepatocyte
Hepatocellular carcinoma is the third leading cause of cancer death worldwide, and it is necessary to elucidate the mechanism of hepatocarcinogenesis. Circadian clock systems have been related in cell cycle and carcinogenesis. In this study, hepatocarcinogenesis induced by DEN administration in mice...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-39288 | biostudies-arrayexpress
TranscriptomicsCandidates for bile acid-dependent PPAR?-target genes in mouse intestinal cells
In addition to their role as a digestive detergent, bile acids have the ability to modulate the expression of genes. The intestinal content of cholic acids (CA) fluctuated in response to the daily feeding-fasting cycle; therefore, we hypothesized that the temporal accumulation of CA may affect the e...
ORGANISM(S): Mus musculus 
2015-08-01 | E-GEOD-55443 | biostudies-arrayexpress
Transcriptomics5/6 nephrectomy (5/6Nx) effect on the liver
Chronic renal failure (CRF) is associated with a decrease in drug metabolism. The present study investigated the repercussions of CRF on liver cytochrome P450 (CYPs), but the mechanisms have been little explored. On the other hand, the expression of several CYP genes exhibits circadian rhythm. Here ...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-35135 | biostudies-arrayexpress
TranscriptomicsExpression data from (bezafibrate treated-wild type, Clock mutant, and PPARalpha-null) mouse liver
A functional interaction between peroxisome proliferator-activated receptor alpha (PPARalpha) and components of the circadian clock has been suggested; however, it remains to be clarified whether those transcriptional factors interact with each other to regulate the expression of their target genes....
ORGANISM(S): Mus musculus 
2010-06-14 | E-GEOD-20513 | biostudies-arrayexpress
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