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TranscriptomicsRNA expression profiles of murine polyploid trophoblast giant cells (TGCs) from day 9.5 implantation sites.
We employed RNA-seq to transcriptionally profile a pure population of hand-dissected polyploid TGCs from embryonic day 9.5. These data provide a set of polyploid-specific TGCs transcripts that will aid in the understanding of TGCs differentiation and endoreplication. TGCs were micro-dissected from d...
ORGANISM(S): Mus musculus 
2013-04-30 | E-GEOD-45782 | biostudies-arrayexpress
TranscriptomicsmicroRNA (miRNA) expression profiles of murine polyploid trophoblast giant cells (TGCs) from day 9.5 implantation sites.
We employed miRNA-seq to profile all miRNAs from a pure population of hand-dissected polyploid TGCs from embryonic day 9.5. These data set of polyploid-specific TGCs microRNAs will provide insights into TGCs differentiation and endoreplication. TGCs were micro-dissected from day E9.5 nine implantati...
ORGANISM(S): Mus musculus 
2013-04-30 | E-GEOD-45784 | biostudies-arrayexpress
TranscriptomicsMurine polyploid trophoblast giant cells (TGCs) from day E9.5 implantation sites (experimental) vs E9.5 diploid embryos (control)
Array-based quantitative genome hybridization (aCGH) was performed to quantify gene copy number across the euchromatic portion of the genome of polyploid TGCs relative to embryonic diploid control cells. DNA was prepared from diploid embryonic cells and purified polyploid TGCs, labeled, and hybridiz...
ORGANISM(S): Mus musculus 
2013-04-30 | E-GEOD-45778 | biostudies-arrayexpress
TranscriptomicsExpression data from RUNX1(41-214)-expressing and Runx1-knockout mice KSL cells
Mutations of RUNX1 are detected in patients with myelodysplastic syndrome (MDS). In particular, C-terminal truncation mutations lack a transcription regulatory domain and have increased DNA binding through the runt homology domain (RHD). The expression of the RHD, RUNX1(41-214), in mouse hematopoiet...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-40155 | biostudies-arrayexpress
TranscriptomicsPRMT1 interacts with leukemia fusion protein AML1-ETO for activation of transcription and transformation
Fusion protein AML1-ETO resulted from t(8;21) translocation is highly related to leukemia development. We have previously shown that the expression of AE9a, a spliced form of AML1-ETO, can rapidly cause leukemia in mouse. To understand how AML1-ETO is involved in leukemia development, we used AE9a l...
ORGANISM(S): Homo sapiens 
2012-06-17 | E-GEOD-28135 | biostudies-arrayexpress
TranscriptomicsExpression data from HeLa cells transiently transfected with control siRNA or SON siRNA
SON is a large Ser/Arg (SR)-related protein localized in nuclear speckles. SON siRNA causes defects in mitotic progression and genome instability. We used microarrays to detail the pattern of gene expression after SON knockdown. HeLa cells were grown in 100 mm dishes and transfected with negative co...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-26888 | biostudies-arrayexpress
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