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TranscriptomicsHigh throughput screening for chemical inducers of stumpy formation in Trypanosoma brucei
During the bloodstream stage of the Trypanosoma brucei lifecycle, the parasite exists as the proliferative slender-form or the non-proliferative, transmissible, stumpy-form. The transition from the slender to stumpy-form is stimulated by a density-dependent mechanism and is important in infection dy...
ORGANISM(S): Trypanosoma brucei brucei 
2014-01-21 | E-GEOD-46483 | biostudies-arrayexpress
ProteomicsDDHD2 interacts with STXBP1 to mediate long-term memory via the generation of saturated free fatty acidsDDHD2 interacts with STXBP1 to mediate long-term memory via the generation of saturated free fatty acids
The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a crucial role in learning and memory, but the mechanisms through which neuronal activity affects the brain's lipid landscape remain largely unexplored. Saturated FFAs, particularly myristic acid (C14:0), strongly inc...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-22 | PXD047812 | Pride
Phospholipase a1  free fatty acids  myristic acid  learning and memory Lipids 
UnknownHematopoietic and stromal DMP1-Cre labeled cells form a unique niche in the bone marrow.
Not available
S-EPMC10725438 | biostudies-literature
TranscriptomicsEffect of Dietary Supplementation of Selenium (Organic vs. Inorganic) on Liver Gene Expression Profile in Beef Heifers
Selenium (Se) is an essential nutrient for beef cattle health and commercial production. The molecular mechanisms responsible for physiological responses of the animal to dietary Se supplementation, however, have not been evaluated. Furthermore, the potential effect of two chemical forms (organic vs...
ORGANISM(S): Bos taurus 
2010-04-28 | E-GEOD-19696 | biostudies-arrayexpress
TranscriptomicsGene expression in alpha SMA Cre-labeled cells in periosteum during early fracture callus formation
Fracture healing is a process that involves many cell populations. In this study we characterized gene expression in a subset of cells involved in fracture healing. αSMACreERT2 mice crossed with Ai9 reporter mice that express tdTomato fluorescent protein after Cre-mediated activation were used as an...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-45156 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Dnmt3L+/- sires compared to offspring of Dnmt3L+/+ sires to investigate the effect of paternal haploinsufficiency for Dnmt3L
There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and the early developing embryo. One corollary to this is that disruption of the establishment of epigenetic state in the gametes of a parent, ...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7384 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype
Astrocyte dysfunction impacts their normal function, including neuronal support, thereby contributing to neurodegenerative pathologies including Alzheimer's disease (AD). Therefore to understand the role of astrocytes in the pathogenesis of age-related disorders we analysed the gene expression profi...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-29652 | biostudies-arrayexpress
TranscriptomicsMitochondrial supplementation at fertilization enhances early developmental outcome
Competent oocytes can be discriminated by BCB staining. Positive stained oocytes are considered more competent than BCB negative oocyte, and injection of BCB+ oocyte extracted mitochondria into BCB negative oocytse can increase fertilisation and blastocyst rate. Here we have analysed the impact of m...
ORGANISM(S): Sus scrofa 
2016-09-01 | E-GEOD-65310 | biostudies-arrayexpress
GenomicsHistone H3K27ac ChIP-seq binding regions in mouse liver
ChIP-seq was used to identify histone H3K27ac bindibg regions in C57BL/6J mouse liver.
ORGANISM(S): Mus musculus 
2018-11-13 | E-MTAB-6994 | biostudies-arrayexpress
UnknownGlobal, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.
Not available
S-EPMC9349325 | biostudies-literature
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