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ProteomicsDDHD2 interacts with STXBP1 to mediate long-term memory via the generation of saturated free fatty acidsDDHD2 interacts with STXBP1 to mediate long-term memory via the generation of saturated free fatty acids
The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a crucial role in learning and memory, but the mechanisms through which neuronal activity affects the brain's lipid landscape remain largely unexplored. Saturated FFAs, particularly myristic acid (C14:0), strongly inc...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-22 | PXD047812 | Pride
Phospholipase a1  free fatty acids  myristic acid  learning and memory Lipids 
UnknownEnhancing Preoperative Outcome Prediction: A Comparative Retrospective Case-Control Study on Machine Learning versus the International Esodata Study Group Risk Model for Predicting 90-Day Mortality in Oncologic Esophagectomy.
Not available
S-EPMC11394558 | biostudies-literature
UnknownStructural Basis of Phosphatidic Acid Sensing by APH in Apicomplexan Parasites.
Not available
S-EPMC6084407 | biostudies-literature
ProteomicsDe novo lysine myristoylation mediates synaptic plasticity and long-term potentiation through membrane association of synaptic proteins
Synaptic plasticity underlying long-term memory is associated with the generation of saturated free fatty acids (sFFAs), in particularly myristic acid, from membrane phospholipids via the phospholipase A1 isoform DDHD2. However, the mechanism through which myristic acid contributes to synaptic plast...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-22 | PXD061811 | Pride
Learning and memory. Synaptic plasticity Lipids  phospholipase a1  ddhd2  n-myristoyl transferase  myristic acid  lysine myristoylation 
GenomicsExome Sequencing for Diseases of the Immune System: X-linked Immunodeficiency with Magnesium Defect, EBV Infection, and Neoplasia (XMEN)

The etiologies of primary immunodeficiencies often yield novel insights about the immune system. Although a genetic etiology has been suspected for patients with abnormally low CD4+ T cells in the absence of HIV infection or any known causes of lymphopenia, no genetic mutation has been de...

phs000365.v1.p1 | EGA
Genomicsena-DATASET-UCL-14-05-2015-18:11:37:007-120 - samples
This dataset contains whole exome data from 8 esophageal adenocarcinoma tumors, that has been subjected to multiregion sequencing, ranging from 3-8 regions per tumor. In total, 40 tumor samples and 8 normal blood samples have been sequenced on Illumina HiSeq 2500 at a median dept of 90x.
EGAD00001001364 | EGA
GenomicsTracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy
Esophageal adenocarcinomas (EACs) are associated with dismal prognosis. Deciphering the evolutionary histories of this disease may shed light on therapeutically tractable targets and reveal changing mutational processes during the disease course and following neoadjuvant chemotherapy (NAC). We exome...
EGAS00001001254 | EGA
GenomicsTRACERx esophageal adenocarcinoma
Data Access Committee EGAC00001000340
EGAC00001000340 | EGA
Genomicsena-DATASET-CRUK-LRI-04-02-2014-11:46:00:265-3 - samples
Paired end Illumina sequencing of whole exomes of multiple tumour regions.
EGAD00001000734 | EGA
GenomicsGenomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
We applied multi-region exome sequencing to 10 clear cell renal carcinomas to resolve the genetic architecture, intra tumour heterogeneity and evolutionary histories of these tumours.
EGAS00001000667 | EGA
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