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ProteomicsMolecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model
LC-MS/MS of Prss37 WT and KO mice male reproductive tract. Title: Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model Authors: Courtney Sutton1,2, Kaori Nozawa1,2, Katarzyna Kent1,2, Alexander Saltzman3, Mei Leng3, Sureshbabu Na...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-07 | MSV000091662 | MassIVE
ProteomicsTestis-specific serine kinase 3 is required for sperm morphogenesis and male fertility
TSSK3 is expressed in elongating sperm and localizes to the sperm tail. To define the essential roles of TSSK3 in vivo and elucidate the mechanisms causing the phenotype, we conducted phosphoproteomics using purified germ cells from Tssk3 HET and KO testes.
ORGANISM(S): Mus musculus (Mouse) 
2023-11-21 | PXD038012 | Pride
Proteomics Oligoteratozoospermia Knockout mouse Teratozoospermia Oligozoospermia 
UnknownDNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors.
Not available
S-EPMC8433497 | biostudies-literature
TranscriptomicsGene expression profiling of mouse luminal uterine epithelium with knockout of ALK3
Bone morphogenetic proteins (BMPs) are transforming growth factor β (TGFβ) family members that regulate the post-implantation and mid-gestation stages of pregnancy. In this study we discovered that signaling via activin-like kinase 3 (ALK3/BMPR1A), a BMP type 1 receptor, is necessary for blastocys...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-73717 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Inhba flox/- Inhbb-/- Amhr2cre/+ activin-deficient granulosa cells vs. wild type
Compares activin deficient granulosa cells (Inhba flox/-; Inhbb-/-; Amhr2cre/+) to wild type granulosa cells Experiment Overall Design: Three replicate wild type granulosa cell samples compared to 2 activin-deficient granulosa cell samples. Each replicate is derived from 2-3 females.
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7150 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Activin-like kinase 2 knockout in mice
Implantation of an embryo in the uterus is a multistep process tightly controlled by an intricate regulatory network of interconnected ovarian, uterine, and embryonic factors. Bone morphogenetic protein (BMP) ligands and receptors are expressed in the pregnant uterus, and BMP2 has been shown to be a...
ORGANISM(S): Mus musculus 
2014-01-07 | E-GEOD-46689 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of ovarian tumors from mice with knockout of DICER and PTEN
The cell of origin of serious ovarian cancer is unknown. To create a mouse model for this lethal cancer and identify early cancer biomarkers, we conditionally deleted both Dicer (essential for microRNA biosynthesis) and Pten (a negative regulator of the PI3K pathway) in the female reproductive tract...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-28720 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of human serious ovarian tumors and fimbria control
The cell of origin of serious ovarian cancer is unknown. To create a mouse model for this lethal cancer and identify early cancer biomarkers, we conditionally deleted both Dicer (essential for microRNA biosynthesis) and Pten (a negative regulator of the PI3K pathway) in the female reproductive tract...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-28721 | biostudies-arrayexpress
UnknownConditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.
Not available
S-EPMC2223289 | biostudies-literature
TranscriptomicsExpression data from testis of day-7 Sohlh1 knock-out mice
Sohlh1 and Sohlh2 encode a germ cell-specific basic helix-loop-helix transcriptional regulator critical in spermatogonial differentiation. Seven-day-old Sohlh1 or Sohlh2 knockout and wild-type testes were arrayed on the Affy 430 2.0 platform. The following mice were analyzed at postnatal day 7: wild...
ORGANISM(S): Mus musculus 
2010-05-07 | E-GEOD-21525 | biostudies-arrayexpress
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