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TranscriptomicsHigh-resolution analysis of copy number changes in circulating and disseminated tumor cells in breast cancer patients
The aim of this study was to establish a single-cell array comparative genomic hybridization (SCaCGH) method providing in-depth genomic analysis of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs). The robustness and resolution limits of the method were estimated with different cel...
ORGANISM(S): Homo sapiens 
2012-11-19 | E-GEOD-27574 | biostudies-arrayexpress
Genomicsena-DATASET-MUG-10-03-2014-08:56:10:089-189 - samples
In order to establish copy number profiles from the various samples we prepared libraries and subjected them to whole-genome sequencing at a shallow sequencing depth (0.1x)
EGAD00001000761 | EGA
Genomicsena-DATASET-MUG-10-03-2014-08:59:23:443-190 - samples
We utilized exome sequencing for DNA obtained from saliva (germline DNA) and the four spatially separated tumor foci and 3 corresponding lymph node metastases
EGAD00001000762 | EGA
Genomicsena-DATASET-MUG-10-03-2014-09:03:11:084-191 - samples
We used targeted deep sequencing to accurately establish the allele frequencies of the mutations identified by exome sequencing
EGAD00001000763 | EGA
GenomicsDivergence between high metastatic tumor burden and low circulating tumor DNA concentration in metastasized breast cancer
Circulating tumor DNA (ctDNA) was reported to represent a highly sensitive biomarker of metastatic cancer disease directly reflecting tumor burden and dynamics. Here we investigated the role of ctDNA in patients with metastatic breast cancer. In an index patient with more than 100,000 circulating tu...
EGAS00001000625 | EGA
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