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TranscriptomicsTranscription profiling of human astrocytes to create a toxicogenomic profile of Mn
Exposure of adult humans to manganese (Mn) has long been known to cause neurotoxicity. Recent evidence also suggests that exposure of children to Mn is associated with developmental neurotoxicity. Astrocytes are critical for the proper functioning of the nervous system, and they play active roles ...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5079 | biostudies-arrayexpress
UnknownTreatment-free remission after dasatinib in patients with chronic myeloid leukaemia in chronic phase with deep molecular response: Final 5-year analysis of DASFREE.
Not available
S-EPMC10524617 | biostudies-literature
GenomicsA Multiplicity of Factors Contributes to Selective RNA polymerase III occupancy of a Subset of RNA polymerase III Genes in Mouse Liver
The genomic loci occupied by RNA polymerase (pol) III have been characterized in human culture cells by genome-wide chromatin immunoprecipitation experiments followed by deep sequencing (ChIP-Seq). These studies have in particular shown that only about 40 % of the annotated 622 human tRNA genes and...
ORGANISM(S): Mus musculus 
2012-01-19 | E-GEOD-33421 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human inflammatory breast carcinoma tumors (luminal, basal and apocrine)
EORTC 10994 is a phase III clinical trial comparing FEC with ET in patients with large operable, locally advanced or inflammatory breast cancer (www.eortc.be). Frozen biopsies were taken at randomisation. RNA was extracted from 100um thickness of 14G core needle biopsies. Adjacent sections were test...
ORGANISM(S): Homo sapiens 
2007-08-14 | E-GEOD-1561 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of breast cancer samples to predict response to anthracycline/taxane chemotherapy .
EORTC 10994 phase III breast cancer clinical trial comparing FEC (5-fluorouracil, cyclophosphamide, epirubicin) with ET (epirubicin, docetaxel). 161 needle biopsies of locally advanced or large operable breast tumours were hybridised to Affymetrix X3P chips. The array data from the ER negative ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6861 | biostudies-arrayexpress
GenomicsQuantifying ChIP-seq data: a spiking method providing an internal reference for sample-to-sample normalization.
Purpose: Description of a spike-adjusting-method (SAM) to normalize ChIP-seq data . Methods: We performed ChIP-seq of POLR3D and POLR2B with mouse liver supplemented with 2.5% of human DNA. Human DNA will be used as an internal control for ChIP-seq quantification. Results: We show that using the SA...
ORGANISM(S): Mus musculus 
2014-04-02 | E-GEOD-52049 | biostudies-arrayexpress
TranscriptomicsMicroarray Expression Data from Haematopoietic Differentiated Human Embryonic Stem Cells
The underlying mechanisms which are responsible and govern early haematopoietic differentiation during development are poorly understood. Gene expression comparison between pluripotent human embryonic stem cells and earliest haematopoietic progenitors may reveal novel transcripts and pathways and p...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29115 | biostudies-arrayexpress
GenomicsGWAS results from Danjou et al, Nature Genetics 2015
GWAS results in epacts format for Danjou et al, Nature Genetics 2015
EGAD00010001722 | EGA
GenomicsGWAS Results from Danjou et al, Nature Genetics 2015
We report genome-wide association study results for the levels of A1, A2 and fetal hemoglobins, analyzed for the first time concurrently. Integrating high-density array genotyping and whole-genome sequencing in a large general population cohort from Sardinia, we detected 23 associations at 10 loci. ...
EGAS00001003645 | EGA
TranscriptomicsCircular RNAs are enriched in anucleate platelets and are a signature of transcriptome degradation
In platelets, splicing and translation occur in the absence of a nucleus. However, the integrity and stability of mRNAs derived from megakaryocyte progenitor cells remain poorly quantified on a transcriptome-wide level. As circular RNAs (circRNAs) are resistant to degradation by exonucleases, their ...
ORGANISM(S): Homo sapiens 
2015-12-12 | E-GEOD-69192 | biostudies-arrayexpress
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