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TranscriptomicsSplicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans
RNA-seq of C.elegans strain N2 (wt) with and without sfa-1 RNAi at adult day 3 and day 15, C. elegans strain DA1116 (eat-2(ad1116)) with and without sfa-1 RNAi at adult day 3, day 15, and day 27, C. elegans strain SS104 (glp-4(bn2)) with and without hrp-2 RNAi at adult day 1, and HeLa cells with and...
ORGANISM(S): Caenorhabditis elegans 
2016-11-29 | E-MTAB-4866 | biostudies-arrayexpress
TranscriptomicsDEPS-1 promotes P granule assembly and RNA interference in C. elegans germ cells
P granules are germ-cell-specific cytoplasmic structures containing RNA and protein and required for proper germ cell development in C. elegans. A new P-granule-associated protein, DEPS-1, whose loss disrupts P granule structure and function was analysed in this study. Genome wide analysis of gene...
ORGANISM(S): Caenorhabditis elegans 
2010-05-26 | E-GEOD-9993 | biostudies-arrayexpress
MetabolomicsBiochemical changes in Robinia pseudoacacia leaflets in dependence of leaf mining, plant age and location

Plant responses to leaf-mining insects are still poorly studied, especially in woody species. Robinia pseudoacacia is widely cultivated in Ukraine, where it is not native. There, the trees are facing increasing damage from the likewise introduced leaf miner species Parectopa robiniel...

2026-03-20 | MTBLS14099 | MetaboLights
ProteomicsInvestigation of inter- and intra-day variability of tear fluid regarding flow rate, protein concentration as well as protein composition
Purpose: Determination of inter- and intra-day variations in tear flow rate, tear fluid protein concentration as well as protein composition regarding their impact for future biomarker studies.Methods: Tear fluid was collected non-invasively from 18 healthy subjects performing Schirmer tests at four...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037811 | Pride
Mass spectrometry Tear fluid Schirmer test Tear flow rate  tear volume Protein concentration 
ProteomicsRat retinae data for use as spectral library, for pathway remodelling as well as protein mapping
Spectral libraries generated by data-dependent acquisition (DDA) are a useful tool for the analysis of data created by data-independent acquisition (DIA) in mass spectrometry. The quality of DIA analysis is dependent on the quality of the spectral library. We used retinal rat tissue to create a spec...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-06-08 | PXD021937 | Pride
Lc-msms Rat Retina proteome Data-independent acquisition Spectral library 
MetabolomicsComputational Ranking of Yerba Mate Small Molecules Based on Their Predicted Contribution to Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus
The aqueous extract of yerba mate, a South American tea beverage made from Ilex paraguariensis leaves, has demonstrated bactericidal and inhibitory activity against bacterial pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). The gas chromatography-mass spectrometry (GC-MS) ana...
2015-03-19 | MTBLS170 | MetaboLights
ProteomicsDon’t die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?
A hallmark of Parkinson’s disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are equally affected. Studies revealed that neurons located more ventrally within the substantia nigra pars compacta have a higher pre...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD037696 | Pride
Neurons Mass spectrometry Proteomic Selective neuronal vulnerability Substantia nigra 
TranscriptomicsTranscription profiling of two human colon cancer cell lines treated with n-3 PUFA docosahexaenoic acid for 3 different time points
Several studies indicate that omega (n)-3 fatty acids may have a potential in the prevention and treatment of cancer. In this study the colon cancer cell lines SW480 and SW620 were treated with the n-3 PUFA DHA (Docosahexaenoic acid) for 3 different time points (12, 24 and 48h). The experiments were...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-MEXP-1014 | biostudies-arrayexpress
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
ProteomicsA spiked human proteomic dataset from human osteogenic differentiated BMSCs and ASCs for use as a spectral library, for modelling pathways as well as protein mapping
This article describes a mass spectrometry data set generated from osteogenic differentiated bone marrow stromal cells (BMSCs) and adipose tissue derived stromal cells (ASCs) of a 24-year old healthy donor spiked with iRT peptides. Cells have been identified via FACS-Analysis positive for CD90 and C...
ORGANISM(S): Homo sapiens (Human) 
2019-10-22 | PXD015026 | Pride
Data-independent acquisition analysis Nanohplc-esi-ms/ms Osteogenic differentiated mesenchymal stem cells 
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