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UnknownMolecular Imbalances Between Striosome and Matrix Compartments Characterize the Pathogenesis and Pathophysiology of Huntington's Disease Model Mouse.
Not available
S-EPMC12429560 | biostudies-literature
MetabolomicsTranscriptomics and Metabolomics Reveal Alterations in Xenobiotic Metabolism and Appearance of Steroidal Alkaloid Metabolites in Mouse Livers after Tomato Consumption

SCOPE: Tomato consumption is associated with many health benefits including lowered risk for developing certain cancers. It is hypothesized that tomato phytochemicals are transported to the liver and other tissues where they alter gene expression in ways that lead to favorable he...

2023-06-13 | MTBLS6715 | MetaboLights
UnknownRisk of Synchronous Distant Recurrence at Time of Locoregional Recurrence in Patients With Stage II and III Breast Cancer (AFT-01).
Not available
S-EPMC5877801 | biostudies-literature
TranscriptomicsSequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in ERGO-1/Argonaute pathway
Argonaute (AGO) proteins interact with distinct classes of small RNAs to direct multiple regulatory outcomes. In many organisms, including plants, fungi and nematodes, cellular RNAdependent RNA polymerases (RdRPs) utilize AGO targets as templates for amplification of silencing signals. Here, we show...
ORGANISM(S): Caenorhabditis elegans 
2010-02-25 | E-GEOD-18714 | biostudies-arrayexpress
GenomicsDistinct epigenomic landscapes of pluripotent and lineage-committed human cells
Human embryonic stem cells share identical genomic sequences with other lineage-committed cells yet possess the remarkable properties of self-renewal and pluripotency. It has been proposed that epigenetic regulatory mechanisms, involving DNA methylation and various chromatin modifications, are at l...
ORGANISM(S): Homo sapiens 
2009-10-13 | E-GEOD-17917 | biostudies-arrayexpress
GenomicsChromatin States in Human ES Cells Reveal Key Regulatory Sequences and Genes Involved in Pluripotency and Self-renewal
Human embryonic stem cells (hESCs) are offering a new therapeutic approach because of their unique ability to proliferate indefinitely in vitro and differentiate into multiple cell types. However, our understanding of the molecular mechanisms of pluripotency and self-renewal remain incomplete. To el...
ORGANISM(S): Homo sapiens 
2009-10-14 | E-GEOD-18292 | biostudies-arrayexpress
TranscriptomicsRestoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle
In this study, we investigated signaling pathways in Skeletal muscle precursors that are altered with aging and age-related deficits in muscle regenerative potential. We performed fluorescence activated cell sorting (FACS) to obtain highly purified skeletal muscle satellite cells from young, middle-...
ORGANISM(S): Mus musculus 
2014-05-08 | E-GEOD-50821 | biostudies-arrayexpress
GenomicsPCGP Ph-like ALL
Background: BCR-ABL1-like, or Ph-like acute lymphoblastic leukemia is characterized by a gene expression profile similar to BCR-ABL1 positive ALL, genetic alterations of lymphoid transcription factor genes, and poor outcome. Sequencing of small numbers of Ph-like ALL cases has identified genetic alt...
EGAS00001000654 | EGA
ProteomicsLKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers
KRAS-mutant lung cancers frequently have inactivating mutations in LKB1, which enhances tumor growth, metastasis, and immune evasion. This study shows that LKB1 suppresses JNK stress signaling, and its loss in KRAS-mutant cells leads to JNK hyperactivation and apoptotic rewiring, making them sensiti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-03-06 | MSV000097246 | MassIVE
GenomicsPCGP Ph-likeALL RNASeq - samples
DATA FILES FOR SJPhLike-RNASeq
EGAD00001001016 | EGA
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