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ProteomicsSkeletal muscle proteomics underpin multifaceted mitochondrial dysfunction in Friedreich´s Ataxia
Friedreich´s Ataxia (FRDA) is a severe neuromuscular disorder caused by a deficiency of the mitochondrial protein frataxin. While some aspects of FRDA pathology are developmental, the causes underlying the steady progression are unclear. The inaccessibility of key affected tissues to sampling is a m...
ORGANISM(S): Homo sapiens (Human) 
2023-12-04 | PXD044554 | Pride
Friedreich´s ataxia Skeletal muscle Mitochondria Frataxin 
TranscriptomicsFoxA1 regulates sweat secretion through Best2 and Nkcc1 ion transporters
Body temperature is maintained in a narrow range in mammals, primarily controlled by sweating. In humans, the dynamic thermoregulatory organ, comprised of 2-4 million sweat glands distributed over the body, can secrete up to 4 liters of sweat per day1, thereby making it possible to withstand high te...
ORGANISM(S): Mus musculus 
2012-01-11 | E-GEOD-32347 | biostudies-arrayexpress
UnknownPerformance of an AI based CAD system in solid lung nodule detection on chest phantom radiographs compared to radiology residents and fellow radiologists.
Not available
S-EPMC8182550 | biostudies-literature
UnknownLack of new antiinfective agents: Passing into the pre-antibiotic age?
Not available
S-EPMC4549771 | biostudies-literature
UnknownThe effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress.
Not available
S-EPMC5434197 | biostudies-literature
UnknownBlood Eosinophils Are Associated with Efficacy of Targeted Therapy in Patients with Advanced Melanoma.
Not available
S-EPMC9104271 | biostudies-literature
UnknownTitration of 124 antibodies using CITE-Seq on human PBMCs.
Not available
S-EPMC9718773 | biostudies-literature
TranscriptomicsTranscription profiling of mouse pancreatic islets on day 14.5 of pregnancy
The inability of the beta-cell to meet the demand for insulin brought about by insulin resistance leads to type 2 diabetes. In adults, beta-cell replication is one of the mechanisms thought to cause the expansion of beta-cell mass. Efforts to treat diabetes require knowledge of the pathways that dri...
ORGANISM(S): Mus musculus 
2010-06-26 | E-MTAB-120 | biostudies-arrayexpress
UnknownNew insight of Arctic cloud parameterization from regional climate model simulations, satellite-based and drifting station data.
Not available
S-EPMC7402221 | biostudies-literature
TranscriptomicsA small RNA response to DNA ends in Drosophila
Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently reported DSB-induced RNAs (diRNAs) or Dicer and D...
ORGANISM(S): Drosophila melanogaster 
2012-08-03 | E-GEOD-38967 | biostudies-arrayexpress
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