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TranscriptomicsZNF750 is a lineage-specific tumor suppressor in squamous cell carcinoma [CaSki]
ZNF750 controls epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by its pathogenic mutations in esophageal squamous cell cancers (SCCs). However, the precise role of ZNF750 in SCC cell biology remains unclear. In this study, we report that ZNF750 is exclusivel...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-86013 | biostudies-arrayexpress
TranscriptomicsZNF750 is a lineage-specific tumor suppressor in squamous cell carcinoma [UMSCC1]
ZNF750 controls epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by its pathogenic mutations in esophageal squamous cell cancers (SCCs). However, the precise role of ZNF750 in SCC cell biology remains unclear. In this study, we report that ZNF750 is exclusivel...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-86014 | biostudies-arrayexpress
TranscriptomicsBCL6 enforces human glioblastoma growth and serves as a novel therapeutic target (expression)
ZBTB transcription factors extensively orchestrate gene transcription during tissue development. However, their roles in glioblastoma multiforme (GBM) remain largely unexplored. Here, through integrated functional screening and expression analyses of 49 human ZBTB genes, we identify that BCL6 is req...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-77053 | biostudies-arrayexpress
TranscriptomicsComprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is a subtype of myeloid leukemia characterized by differentiation block at the promyelocyte stage. Besides the presence of chromosomal rearrangement t(15;17) leading to formation of PML-RARA fusion, other genetic alterations have also been implicated in APL. ...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-77946 | biostudies-arrayexpress
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