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Transcriptomics"Calling Cards" for DNA-binding proteins in mammalian cells
The ability to chronicle transcription factor binding events throughout the development of an organism would facilitate mapping of transcriptional networks that control cell fate decisions. We describe a method for permanently recording protein-DNA interactions in mammalian cells. We endow transcri...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-34791 | biostudies-arrayexpress
GenomicsMultiplexed identification of the genomic targets of DNA-binding proteins
Transcription factors direct gene expression, and so there is much interest in mapping their genome-wide binding locations. M-BM- Current methods do not allow for the multiplexed analysis of TF binding, and this limits their throughput. We describe a novel method for determining the genomic target g...
ORGANISM(S): Saccharomyces cerevisiae 
2011-02-18 | E-GEOD-27381 | biostudies-arrayexpress
TranscriptomicsExamination of the role of BMP signaling in patterning of human pluripotent stem cell derived mid/hindgut spheroids and maintenance of this patterning in organoids transplanted under mouse kidney capsules.
The goal of this study was to test the hypothesis that BMP signaling regulates patterning of human CDX2+ gut tube cultures (Spence et al 2011, Watson et al. 2014). The study is comprised of 2 separate experiments. The first experiment was to determine the immediate impact of BMP signaling on CDX2+ g...
ORGANISM(S): Homo sapiens 
2017-04-20 | E-MTAB-5658 | biostudies-arrayexpress
TranscriptomicsTranscription Factor Regulation and Chromosome Dynamics in Pseudohyphal Growth
Pseudohyphal growth is a developmental pathway seen in some strains of yeast, in which cells elongate and form multicellular filaments in response to environmental stresses. Regulation of this process is complex and involves multiple signaling pathways and a large number of transcription factors (T...
ORGANISM(S): Saccharomyces cerevisiae 
2014-02-11 | E-GEOD-54831 | biostudies-arrayexpress
UnknownFine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.
Not available
S-EPMC4321445 | biostudies-literature
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