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TranscriptomicsTIAR represses c-Myc biosynthesis following ultraviolet light irradiation
RNA was isolated from material that had been subjected to immunoprecipitation (IP) from RKO cells that were either left untreated or irradiated with 20 J/m2 UVC and collected 1h later; IP assays were carried out using either an antibody recognizing RNA-binding protein TIAR, or using a control IgG1 a...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-1433 | biostudies-arrayexpress
TranscriptomicsIdentification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach.
Employing MCT-1 oncogene mediated transformation of immortalized breast epithelial MCF10A cells; we characterized the largely reciprocal association of these two RBPs with target mRNAs and their influence on protein expression vis-à-vis cellular transformation. Using a ribonomics approach, we ident...
ORGANISM(S): Homo sapiens 
2008-07-29 | E-GEOD-12215 | biostudies-arrayexpress
TranscriptomicsConcurrent Versus Individual Binding of HuR and AUF1 to Common Labile Target mRNAs
RNA was isolated from material that had been immunoprecipitated (IP) from Hela cells using antibodies recognizing RNA-binding proteins HuR or AUF1, as well as using a control IgG1 antibody. RNA was reverse-transcribed in the presence of [alpha-33P]dCTP and the radiolabeled product used to hybridize ...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-1361 | biostudies-arrayexpress
TranscriptomicsMicroRNA-520c-3p targets eIF4GII and acts as a tumor suppressor in diffuse large B cell lymphoma
Deregulation of the translational machinery is emerging as a critical contributor to lymphomagenesis. Various miRNA alterations have been identified in lymphoma, but their role in disrupting the cap-dependent translation regulation complex remains poorly understood. Here, we demonstrate the translat...
ORGANISM(S): Homo sapiens 
2014-03-19 | E-GEOD-40489 | biostudies-arrayexpress
TranscriptomicsHNRNPU RNA targets and DNA methylation changes during neural differentiation
This study investigates the molecular mechanisms by which the DNA/RNA-binding protein HNRNPU regulates gene expression during early human neural development. Pathogenic variants in HNRNPU cause a severe neurodevelopmental disorder, but the underlying mechanisms remain poorly understood. To explore t...
ORGANISM(S): Homo sapiens 
2026-02-02 | E-MTAB-14910 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of aging human muscle
We analyzed expression of 81 normal muscle samples from humans of varying ages, and have identified a molecular profile for aging consisting of 250 age-regulated genes. This molecular profile correlates not only with chronological age but also with a measure of physiological age. We compared the tra...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5086 | biostudies-arrayexpress
TranscriptomicsATM regulates a DNA damage response post-transcriptional RNA operon in lymphocytes
Maintenance of genomic stability depends on the DNA damage response (DDR), a biological barrier in early stages of cancer development. Failure of this response results in genomic instability and high predisposition toward lymphoma, as seen in patients with ataxia-telangiectasia mutated (ATM) dysfunc...
ORGANISM(S): Homo sapiens 
2011-01-05 | E-GEOD-25848 | biostudies-arrayexpress
TranscriptomicsMNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL
The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and show a distinct distribution of MNK1 and ...
ORGANISM(S): Homo sapiens 
2014-11-18 | E-GEOD-61691 | biostudies-arrayexpress
TranscriptomicsDistinct inhibitory effects on mTOR signaling by ethanol and INK128 in diffuse large B-cell lymphoma
The mechanistic target of rapamycin, (mTOR) kinase plays a pivotal role in controlling critical cellular growth and survival pathways, and its aberrant induction is implicated in cancer pathogenesis. Therefore, suppression of active mTOR signaling has been of great interest to researchers; several m...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-62790 | biostudies-arrayexpress
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