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GenomicsASXL1 Mutations Promote Myeloid Transformation Through Loss of PRC2-Mediated Gene Repression
Recurrent somatic ASXL1 mutations occur in patients with myelodysplasia (MDS), myeloproliferative neoplasms (MPN), and acute myeloid leukemia (AML), and are associated with adverse outcome. Despite the genetic and clinical data implicating ASXL1 mutations in myeloid malignancies, the mechanisms of t...
ORGANISM(S): Homo sapiens 
2012-08-21 | E-GEOD-38861 | biostudies-arrayexpress
GenomicsGenome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
RNA-guided genome editing with the CRISPR-Cas9 system has great potential for basic and clinical research, but the determinants of targeting specificity and the extent of off-target cleavage remain insufficiently understood. Using chromatin immunoprecipitation and high-throughput sequencing (ChIP-se...
ORGANISM(S): Homo sapiens 
2014-05-18 | E-GEOD-55887 | biostudies-arrayexpress
UnknownA Rare Association of Congenital Asplenia with Jejunal Arteriovenous Malformation.
Not available
S-EPMC5659234 | biostudies-literature
UnknownEffectiveness of rivaroxaban in preventing cerebral venous thromboembolism: a systematic review and meta-analysis.
Not available
S-EPMC10990339 | biostudies-literature
UnknownUltrafast Near-Infrared Light-triggered Intracellular Uncaging to Probe Cell Signaling.
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S-EPMC5697715 | biostudies-literature
UnknownPopulation-Based Psychiatric Comorbidity in Children and Adolescents With Autism Spectrum Disorder: A Meta-Analysis.
Not available
S-EPMC9186340 | biostudies-literature
UnknownThe Association of HLA Alleles and Haplotypes with Age of Disease Onset in Pakistani Psoriatic Patients.
Not available
S-EPMC9932843 | biostudies-literature
UnknownIn vitro and in silico assessment of probiotic and functional properties of Bacillus subtilis DE111®.
Not available
S-EPMC9880548 | biostudies-literature
UnknownEpigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes.
Not available
S-EPMC11819886 | biostudies-literature
UnknownEpigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes.
Not available
S-EPMC10996669 | biostudies-literature
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