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GenomicsUnbiased, Genome-wide in vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-specific Liver Gene Expression
We have used a simple and efficient method to identify condition-specific transcriptional regulatory sites in vivo to help elucidate the molecular basis of sex-differences in transcription, which are widespread in mammalian tissues and affect normal physiology, drug response, inflammation and diseas...
ORGANISM(S): Mus musculus 
2010-09-28 | E-GEOD-21777 | biostudies-arrayexpress
TranscriptomicsPolyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (mRNA)
In Huntington's disease (HD), polyglutamine expansions in the huntingtin (Htt) protein cause subtle changes in cellular functions that, over-time, lead to neurodegeneration and death. Studies have indicated that activation of the heat shock response can reduce many of the effects of mutant Htt in d...
ORGANISM(S): Mus musculus 
2012-06-18 | E-GEOD-38001 | biostudies-arrayexpress
GenomicsDirect Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (ChIP-Seq)
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study, we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds direct...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-33653 | biostudies-arrayexpress
TranscriptomicsPolyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1
This SuperSeries is composed of the following subset Series: GSE38000: Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (ChIP-Seq) GSE38001: Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (mRNA) Refer to individual Series
ORGANISM(S): Mus musculus 
2012-06-18 | E-GEOD-38002 | biostudies-arrayexpress
GenomicsPolyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (ChIP-Seq)
In HuntingtonM-bM-^@M-^Ys disease (HD), polyglutamine expansions in the huntingtin (Htt) protein cause subtle changes in cellular functions that, over-time, lead to neurodegeneration and death. Studies have indicated that activation of the heat shock response can reduce many of the effects of mutan...
ORGANISM(S): Mus musculus 
2012-06-19 | E-GEOD-38000 | biostudies-arrayexpress
GenomicsMethylation_Controls
Methylation Control samples using 450K Array
EGAD00010001449 | EGA
GenomicsE.Stieglitz_20171027_dataset_aligned - samples
Description not provided
EGAD00001003794 | EGA
GenomicsMethylation_JMML
Methylation JMML samples using 450K Array
EGAD00010001450 | EGA
GenomicsGenome-wide DNA Methylation is Predictive of Outcome in Juvenile Myelomonocytic Leukemia
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder of childhood caused by mutations in the Ras pathway. Outcomes in this disease vary dramatically from spontaneous resolution with little or no treatment to rapid relapse after hematopoietic stem cell transplantation. Given the h...
EGAS00001002700 | EGA
GenomicsDNA Methylation in JMML
Data Access Committee EGAC00001000751
EGAC00001000751 | EGA
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