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TranscriptomicsMicroarray Analysis of Genes Regulated by Macrophage-Conditioned Media Treatment of Human Pre-Adipocytes
A major development in the study of obesity is the recognition that the condition is characterised by chronic mild inflammation. Within adipose tissue, this involves the infiltration of macrophages, as well as the direct inflammatory response of the adipocytes and pre-adipocytes. This study has us...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-27503 | biostudies-arrayexpress
TranscriptomicsHypoxia-induced modulation of gene expression in human adipocytes - A microarray study
Obesity is characterised by expansion of white adipose tissue, accompanied by an inflamatory response. It has been proposed that the inflammatory state observed may be linked to relative hypoxia in clusters of adipocytes distant from vasculature. Adipose tissue hypoxia has been observed in both an...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-34007 | biostudies-arrayexpress
TranscriptomicsPolidocanol injury wildtype versus Myd88 KO trachea
Nf-kB activity is associated with the key pathological features of chronic respiratory diseases including epithelial remodelling, excess mucous production, and submucosal gland hyperplasia. However, the role of Nf-kB activity in airway epithelial differentiation remains controversial. In the prese...
ORGANISM(S): Mus musculus 
2011-03-17 | E-GEOD-17268 | biostudies-arrayexpress
TranscriptomicsEffect of IL6 level on gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity
A number of chronic, age-related diseases are associated with elevated markers of inflammation such as interleukin-6 (IL-6). In this study, we investigated the hypothesis that sedentary individuals with disparate basal serum IL-6 respond differentially to a structured physical activity programme. Ge...
ORGANISM(S): Homo sapiens 
2010-08-03 | E-GEOD-12384 | biostudies-arrayexpress
TranscriptomicsGene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity
Gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity was investigated in sedentary middle-aged men (mean age 52.6 years and BMI 29.1) who undertook a 24-week physical activity programme with blood sampling in the pre-exercise period , at the end of 24-w...
ORGANISM(S): Homo sapiens 
2010-08-03 | E-GEOD-12385 | biostudies-arrayexpress
TranscriptomicsMicroarray Analysis of Genes Regulated by Macrophage-Conditioned Media Treatment of Human Adipocytes
A major development in obesity research is the recognition that the condition is characterized by chronic mild inflammation. Within adipose tissue, this involves the infiltration of macrophages as well as a direct inflammatory response of adipocytes. This study has used Agilent whole-genome microarr...
ORGANISM(S): Homo sapiens 
2010-04-08 | E-GEOD-14312 | biostudies-arrayexpress
TranscriptomicsGene expression changes in femur bone induced by skeletal muscle unloading
Gene expression changes in femur bone induced by acute skeletal muscle unloading, which leads to physiological changes including muscle atrophy, weakness and results in bone remodelling and subsequent loss of bone mass, was investigated by hind-limb suspension (HLS) treatment of Male ICR mice (28–32...
ORGANISM(S): Mus musculus 
2010-12-21 | E-GEOD-11933 | biostudies-arrayexpress
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