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ProteomicsIdentification of bone marrow and peripheral blood plasma extracellular vesicle protein biomarker signatures for multiple myeloma diagnosis and staging
Multiple myeloma (MM) is a hematological malignancy characterised by the clonal proliferation of abnormal plasma cells within the bone marrow (BM). Despite advances in treatment that have improved survival, the disease remains incurable. MM diagnosis requires invasive bone marrow biopsy to quantify ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD069556 | Pride
Machine learning Cancer Multiple myeloma Extracellular vesicles Biomarker signature Proteomic 
ProteomicsMultiple myeloma derived extracellular vesicle uptake by monocyte cells stimulates secretion of IL-6 and MMP9 and promotes cancer cell migration and proliferation.
Multiple Myeloma (MM) is an incurable haematological malignancy caused by uncontrolled growth of plasma cells. MM pathogenesis is largely attributed to crosstalk between plasma cells and the bone marrow microenvironment (BMM), where extracellular vesicles (EVs) are reported to play a role. Improved ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-26 | PXD047285 | Pride
Multiple myeloma Extracellular vesicle Cancer cell migration. 
ProteomicsCyclophilin A isomerization of Septin 2 mediates abscission during cytokinesis
The isomerase activity of Cyclophilin A is important for midbody abscission during cell division, however to date, midbody substrates remain unknown. In this study, we report that the GTP-binding protein Septin 2 interacts with Cyclophilin A. We highlight a dynamic series of Septin 2 phenotypes at t...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042822 | Pride
Human Cancer Cyclophilin a Cytokinesis Septin 2 K562 cells 
Unknown2023 Canadian Surgery Forum: Sept. 20-23, 2023.
Not available
S-EPMC10718225 | biostudies-literature
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