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MetabolomicsNMR spectroscopy analysis reveals altered metabolic homeostasis in Arabidopsis seedlings treated with a cytokinesis inhibitor
Not available
ORGANISM(S): Arabidopsis thaliana 
ST001478 | MetabolomicsWorkbench
ProteomicsComparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis
Successful completion of cytokinesis requires the coordinated activities of diverse cellular components including membranes, cytoskeletal elements and chromosomes. Biochemical analysis of cytokinesis is challenging due to its dynamic and rapid nature that necessitates the establishment of robust met...
ORGANISM(S): Homo sapiens (Human) 
2018-02-07 | PXD008451 | Pride
Cytokinesis Monopolar cytokinesis Phosphoproteome Cell cycle 
TranscriptomicsThe effect of aneuploidy on gene expression
Analysis of the gene expression changes observed in aneuploid b1 integrin YYFF MEFs generated as a result of repeated cytokinesis failure compared to tetraploid wild-type MEFs or tetraploid b1YYFF integrin MEFs. The results reveal aneuploidy-specific gene expression changes, both up-and downregulate...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-23729 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and myo1 knock out yeast to examine differential gene expression patterns in evolved mutants that can successfully perform cytokinesis
In general, yeast strains with myo1 knocked out cannot perform cytokinesis, but some evolve new ways of accomplishing the task. This is an examination of differential gene expression patterns in a selection of evolved mutants that can successfully perform cytokinesis. The purpose is to attempt a m...
ORGANISM(S): Saccharomyces cerevisiae 
2008-11-24 | E-TABM-559 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of wild type and myo1 knock out yeast to identify aneuploidies and CNVs in evolved mutants that can successfully perform cytokinesis
In general, yeast strains with myo1 knocked out cannot perform cytokinesis, but some evolve new ways of accomplishing the task. This is an examination of aneuploidies and CNVs in a selection of evolved mutants that can successfully perform cytokinesis. The purpose is to attempt a molecular charact...
ORGANISM(S): Saccharomyces cerevisiae 
2008-11-24 | E-TABM-557 | biostudies-arrayexpress
TranscriptomicsGene expression in diploid and evolved tetraploid RPE-1 and BJ-1 cells
Both diploid RPE-1 and BJ-1 cells were made tetraploid by transient treatment with the cytokinesis inhibitor DCD. Proliferating tetraploids from both BJ-1 and RPE-1 were selected and isolated. The gene expression profiles of the proliferating tetraploid cells were then compared to the diploids from ...
ORGANISM(S): Homo sapiens 
2014-05-22 | E-GEOD-57864 | biostudies-arrayexpress
ProteomicsNAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.
Supporting raw MS data for paper (DOI:10.1083/jcb.202303082) by Paul S. et al., titled "NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis". Index of MS supporting files uploaded: - Related to Figure 6A;S4A (AO3556-AO3579: whole proteome (Unimod: 35; 2016; 4)). -...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-01 | MSV000093220 | MassIVE
ProteomicsThe Flemmingsome reveals an ESCRT-to-membrane coupling required for cytokinesis
Cytokinesis requires the constriction of ESCRT-III filaments on the midbody side, where abscission occurs. After ESCRT recruitment at the midbody, it is not known how the ESCRT-III machinery localizes to the abscission site. We obtained the proteome of intact, post-abscission midbodies (Flemmingsome...
ORGANISM(S): Homo sapiens (Human) 
2020-05-22 | PXD013219 | Pride
Human Escrt machinery Cytokinesis Midbody Qexactive Lc-ms/ms 
ProteomicsCyclophilin A isomerization of Septin 2 mediates abscission during cytokinesis
The isomerase activity of Cyclophilin A is important for midbody abscission during cell division, however to date, midbody substrates remain unknown. In this study, we report that the GTP-binding protein Septin 2 interacts with Cyclophilin A. We highlight a dynamic series of Septin 2 phenotypes at t...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042822 | Pride
Human Cancer Cyclophilin a Cytokinesis Septin 2 K562 cells 
TranscriptomicsThe DNA-helicase HELLS drives ALK- ALCL proliferation by the transcriptional control of a cytokinesis-related program
Deregulation of chromatin modifiers, including DNA helicases, are emerging as one of the mechanism underlying the transformation of anaplastic lymphoma kinase negative (ALK−) anaplastic large cell lymphoma (ALCL). We recently identified the DNA helicase HELLS as central for proficient ALK-ALCL proli...
ORGANISM(S): Homo sapiens 
2022-12-15 | E-MTAB-9918 | biostudies-arrayexpress
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