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One of the main hallmarks of aging is aging-associated inflammation, also known as inflammaging. In this study, by comparing young and old mice using LC-MS profiling, we show that immunoglobulins are the proteins that are most increased with age in plasma. This observation appears to have been previ...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-03 | PXD051031 | Pride
Replicative senescence (RS) as a model has become the central focus of research into cellular aging in vitro. Despite decades of study, this process through which cells cease dividing is not fully understood in culture, and even much less so in vivo during development and with aging. Here, we revisi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD028799 | Pride
The capsular serotype has long been associated with the virulence of Streptococcus pneumoniae. Here we present an in-depth study of phenotypic and genetic differences between serotype 3 and serogroup 11 S. pneumoniae clinical isolates from both the general and indigenous populations of Australia. Bo...
ORGANISM(S): Streptococcus pneumoniae 
The primary cilium is a signaling compartment that interprets Hedgehog signals through changes of its protein, lipid and second messenger compositions. Here, we combine proximity labeling of cilia with quantitative mass spectrometry to unbiasedly profile the time-dependent alterations of the ciliary...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-07 | PXD024361 | Pride
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