Sort   by:  
 Page size 
ProteomicsPlasma and kidney proteome profiling combined with laser capture microdissection reveal large increases in immunoglobulins with age
One of the main hallmarks of aging is aging-associated inflammation, also known as inflammaging. In this study, by comparing young and old mice using LC-MS profiling, we show that immunoglobulins are the proteins that are most increased with age in plasma. This observation appears to have been previ...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-03 | PXD051031 | Pride
Aging Complement Kidney Laser capture microdissection Proteomics Immunoglobulins 
ProteomicsEffects of human immunoglobulins on Cryptococcus neoformans morphology and proteome
Cryptococcus neoformans (Cn) is the main cause of fungal meningitis (CM) in people living with HIV. Perturbations in levels of normal immunoglobulin (Ig) levels are observed in these individuals, but their association with CM pathogenesis is unclear. Here, we investigated the physical and biological...
ORGANISM(S): Cryptococcus neoformans 
2026-01-26 | PXD072710 | Pride
Igm Cryptococcal capsule Cryptococcus neoformans Human immunoglobulins Igg Hiv Cryptococcal proteome. And iga Glucuronoxylomannan 
ProteomicsAstrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion
Using multi-omics analyses including RNAseq, RT-PCR, RACE-PCR, and shotgun proteomic with enrichment strategies, we demonstrated that newborn rat astrocytes produce neural immunoglobulin constant and variable heavy chains as well as light chains. However, their edification is different from the ones...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-05-10 | PXD040562 | Pride
Immunoglobulins Astrocytes 
GenomicsInvolvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm I
Involvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm I
PRJNA431589 | ENA
TranscriptomicsMurine study of combined LPS and modified immunoglobulins associated gene expression changes in vivo
We systematically assessed the transcriptomic changes of lipopolysaccharides (LPS) of mice upon stimulation with immunoglobulins (IVIg), modified immunoglobulins (modIVIg) or vehicle controls in kidney, blood and liver in vivo. Data indicate different in vivo responses to LPS in conjunction with IVI...
ORGANISM(S): Mus musculus 
2014-07-01 | GSE55694 | GEO
TranscriptomicsMurine study of combined LPS and modified immunoglobulins associated gene expression changes in vivo
We systematically assessed the transcriptomic changes of lipopolysaccharides (LPS) of mice upon stimulation with immunoglobulins (IVIg), modified immunoglobulins (modIVIg) or vehicle controls in kidney, blood and liver in vivo. Data indicate different in vivo responses to LPS in conjunction with IVI...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-55694 | biostudies-arrayexpress
GenomicsInvolvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm II
Involvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm II
PRJNA431588 | ENA
TranscriptomicsInvolvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm II
Background—Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in older individuals. Currently, therapeutic options are limited to surgical interventions. Although it has long been known that AAA tissue is enriched in B cells and immunoglobulins, their involvemen...
ORGANISM(S): Mus musculus 
2018-04-25 | GSE109639 | GEO
TranscriptomicsInvolvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm I
Background—Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in older individuals. Currently, therapeutic options are limited to surgical interventions. Although it has long been known that AAA tissue is enriched in B cells and immunoglobulins, their involvemen...
ORGANISM(S): Mus musculus 
2018-04-25 | GSE109638 | GEO
ProteomicsSite-specific N-glycosylation Characterization of Monoclonal Immunoglobulins in Multiple Myeloma
Monoclonal immunoglobulins (M-proteins) produced by clonal plasma cells are the main cause of multiple myeloma (MM), and hypocomplementemia is observed in some patients with MM. Previous studies have suggested that the glycosylation of immunoglobulins is associated with complement-mediated effector ...
ORGANISM(S): Homo Sapiens 
2024-06-27 | PXD053451 |
Sort   by:  
 Page size