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Abnormal NF-kB2 activation has been reported in several types of human leukemia and lymphomas although the exact mechanisms and affected pathways are not clear. We have investigated these questions through the use of a unique transgenic mouse model with lymphocyte-targeted expression of p80HT, a lym...
ORGANISM(S): Mus musculus 
The New Zealand Black (NZB) mouse is a leukemic model. A cell line, LNC, was derived from malignant cells in the lymph node of a 1 year old NZB. We treated LNC in vitro with 20uM IL-10 antisense, untreated control or scrambled sense and RNA was collected at 24 hours.
ORGANISM(S): Mus musculus 
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