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TranscriptomicsmiRNA-sequencing of human pancreatic islets and enriched beta-cells
Recent advances in the understanding of the genetics of type 2 diabetes (T2D) susceptibility have focused attention on the regulation of transcriptional activity within the pancreatic beta-cell. MicroRNAs (miRNAs) represent an important component of regulatory control, and have proven roles in the d...
ORGANISM(S): Homo sapiens 
2013-06-07 | E-GEOD-47720 | biostudies-arrayexpress
UnknownEpigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study.
Not available
S-EPMC4724884 | biostudies-literature
TranscriptomicsVariability of gene expression profiles in human blood and lymphoblastoid cell lines
Readily accessible samples such as peripheral blood or cell lines are increasingly being used in large cohorts to characterise gene expression differences between a patient group and healthy controls. However, cell and RNA isolation procedures and the variety of cell types that make up whole blood c...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-30916 | biostudies-arrayexpress
UnknownThe miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis.
Not available
S-EPMC3555946 | biostudies-literature
TranscriptomicsThe human pancreatic islet transcriptome: impact of pro-inflammatory cytokines
We have used RNA-seq to identify transcripts, including splice variants, expressed in human islets of Langerhans under control condition or following exposure to the pro-inflammatory cytokines interleukin-1β (IL-1β) and interferon-γ (IFN-γ). A total of 29,776 transcripts were identified as expressed...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-35296 | biostudies-arrayexpress
UnknownHnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.
Not available
S-EPMC2682018 | biostudies-literature
UnknownClonal hematopoiesis is associated with reduced response to atezolizumab in non-small cell lung cancer.
Not available
S-EPMC12458721 | biostudies-literature
TranscriptomicsRNA-sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate
Pancreatic beta-cell dysfunction and death are central in the pathogenesis of type 2 diabetes. Saturated fatty acids cause beta-cell failure and contribute to diabetes development in genetically predisposed individuals. Here we used RNA-sequencing to map transcripts expressed in five palmitate-treat...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-53949 | biostudies-arrayexpress
UnknownSAIL--a software system for sample and phenotype availability across biobanks and cohorts.
Not available
S-EPMC3035801 | biostudies-literature
GenomicsPopulation-based whole-genome bisulfite sequencing in multiple human tissues
Analysis of human population methylome variation in adipose tissue and whole blood at single-site resolution by whole genome bisulfite sequencing.
ORGANISM(S): Homo sapiens 
2015-10-26 | E-MTAB-3549 | biostudies-arrayexpress
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