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Pancreatic beta-cell dysfunction and death are central in the pathogenesis of type 2 diabetes. Saturated fatty acids cause beta-cell failure and contribute to diabetes development in genetically predisposed individuals. Here we used RNA-sequencing to map transcripts expressed in five palmitate-treat...
ORGANISM(S): Homo sapiens 
Therapies currently in preclinical development for prion disease seek to lower prion protein (PrP) expression in the brain. Trials of such therapies are likely to rely on quantification of PrP in cerebrospinal fluid (CSF) as a pharmacodynamic biomarker and possibly as a trial endpoint. Studies using...
ORGANISM(S): Homo Sapiens Rattus Norvegicus Mus Musculus Macaca Fascicularis 
2019-11-19 | PXD014781 | panorama
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
WTCCC genome-wide case-control association study for Autoimmune Thyroid Disease (ATD) - Combined Controls.
WTCCC genome-wide case-control association study for Autoimmune Thyroid Disease (ATD) using the 1958 British Birth Cohort collection as controls.
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