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ProteomicsSystemic Pathogenesis of Different Phenotypes of Heart Failure with Preserved Ejection Fraction.
Heart failure with preserved ejection fraction (HFpEF) accounts for ~50% of all heart failure cases. HFpEF is a heterogeneous condition with poorly understood molecular mechanisms related to different forms including acute and chronic HFpEF. Here, we utilised plasma samples collected from patients w...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024012 | Pride
Biomarkers Heart failure with preserved ejection fraction Plasma Hypertrophic cardiomyopathy Lc-ms/ms 
ProteomicsMatrix directs trophoblast differentiation in a bioprinted organoid model of early placental development
Trophoblast organoids offer a unique opportunity to study mechanisms orchestrating placental growth and development during pregnancy. However, many organoid cultures rely on extracellular matrix reagents that are highly variable and unable to be tuned to reflect in vivo tissues. Here we describe the...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD056796 | Pride
Matrigel Shotgun Organoid Bioprinting Placenta 
ProteomicsMaternal plasma proteome profiling of biomarkers for stratification of early-onset and late-onset preeclampsia
Hypertension in pregnancy is the leading cause of morbidity and mortality in pregnancy, affecting up to 10% of all gestations1. Hypertensive disorders of pregnancy include chronic hypertension, gestational hypertension, eclampsia and pre-eclampsia, all of which increase the risk of complications in ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD026931 | Pride
Plasma Preeclampsia Biomarkers Lc-ms/ms 
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