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TranscriptomicsThe Nucleus Accumbens Shell and Central Nucleus of the Amygdala of Alcohol-Preferring Rats Following Binge-Drinking
The objective of this study was to determine changes in gene expression within the extended amygdala following binge-like drinking by alcohol-preferring (P) rats. Adult male P rats were given 1-hr access to 15 and 30% ethanol (EtOH) three times daily for 8 weeks. Rats (n = 10/time point for EtOH and...
ORGANISM(S): Rattus norvegicus 
2009-12-30 | E-GEOD-15407 | biostudies-arrayexpress
TranscriptomicsEthanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression.
Compared gene expression in lymphoblasoid cell lines from alcholics and controls and 24 hr treatment with ethanol. To elucidate the effects of a controlled exposure to ethanol on gene expression, we studied lymphoblastoid cell lines (LCLs) from 21 alcoholics and 21 controls. We cultured each cell li...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-52553 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of yeast gcn2, gcn4 and gln3 deletion mutants treated with rapamycin or 3-amino-1,2,4-triazole (3-AT)
Two nutrient sensing and regulatory pathways, the general amino acid control (GAAC) and the target of rapamycin (TOR), control yeast growth and metabolism in response to changes in nutrient availability. Starvation for amino acids activates the GAAC pathway, involving Gcn2p phosphorylation of eIF2 ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-03-07 | E-GEOD-15254 | biostudies-arrayexpress
TranscriptomicsCandidate genes for alcohol preference in alcohol-preferring and non-preferring reciprocal congenic rats
The goal of this study was to identify candidate genes that may influence alcohol consumption by comparing gene expression in 5 brain regions of alcohol-naïve iP and P.NP rats. Background: Selectively bred P (alcohol preferring) and NP (alcohol non-preferring) rats differ greatly in alcohol prefere...
ORGANISM(S): Rattus norvegicus 
2009-12-30 | E-GEOD-15415 | biostudies-arrayexpress
TranscriptomicsEthanol exposure disrupts extraembryonic microtubule cytoskeleton and embryonic blastomere cell adhesion, producing epiboly and gastrulation defects
Gene expression was measured using microarrays in 8 hour postfertilization embryos, comparing control versus ethanol-treated (2 to 8 hours postfertilization) embryos. This experiment was performed to determine the gene expression changes that occur in response to ethanol treatment as a model of feta...
ORGANISM(S): Danio rerio 
2014-07-09 | E-GEOD-48380 | biostudies-arrayexpress
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