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This dataset contains quantitative, bottom-up DIA proteomics data generated as part of a larger study entitled "AI-Guided CRISPR Screen Reveals Repurposed Drugs as Topical Psoriasis Therapeutics," and is organized into two complementary sub-studies.Sub-study 1 – Pharmacological Rescue in a Mouse Pso...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-05-21 | PXD071833 | Pride
Human genetics as well as pharmacological intervention reveal that Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) plays a key role in regulating the levels of plasma low density lipoprotein cholesterol (LDL-C). Here we demonstrate that the compound PF-06446846 inhibits translation of PCSK9 by...
ORGANISM(S): Homo sapiens (Human) 
2017-03-27 | PXD005822 | Pride
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